JACC: Basic to Translational Science (Sep 2019)
Platelet Acetyl-CoA Carboxylase Phosphorylation
- Shakeel Kautbally, MD,
- Sophie Lepropre, PhD,
- Marie-Blanche Onselaer, PhD,
- Astrid Le Rigoleur, MD,
- Audrey Ginion, MS,
- Christophe De Meester de Ravenstein, PhD,
- Jerome Ambroise, PhD,
- Karim Z. Boudjeltia, PhD,
- Marie Octave, MS,
- Odile Wéra, MS,
- Alexandre Hego, BSc,
- Joël Pincemail, PhD,
- Jean-Paul Cheramy-Bien,
- Thierry Huby, PhD,
- Martin Giera, PhD,
- Bernhard Gerber, MD, PhD,
- Anne-Catherine Pouleur, MD, PhD,
- Bruno Guigas, PhD,
- Jean-Louis Vanoverschelde, MD, PhD,
- Joelle Kefer, MD, PhD,
- Luc Bertrand, PhD,
- Cécile Oury, PhD,
- Sandrine Horman, PhD,
- Christophe Beauloye, MD, PhD
Affiliations
- Shakeel Kautbally, MD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Sophie Lepropre, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Marie-Blanche Onselaer, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Astrid Le Rigoleur, MD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Audrey Ginion, MS
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Christophe De Meester de Ravenstein, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Jerome Ambroise, PhD
- Center for Applied Molecular Technologies, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Karim Z. Boudjeltia, PhD
- Laboratory of Experimental Medecine (ULB 222 unit), Centre Hospitalier Universitaire de Charleroi, Université Libre de Bruxelles, Charleroi, Belgium
- Marie Octave, MS
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Odile Wéra, MS
- Laboratory of Thrombosis and Hemostasis, GIGA-Cardiovascular Sciences, Department of Cardiology, Université de Liège, Liège, Belgium
- Alexandre Hego, BSc
- Laboratory of Thrombosis and Hemostasis, GIGA-Cardiovascular Sciences, Department of Cardiology, Université de Liège, Liège, Belgium
- Joël Pincemail, PhD
- Department of Cardiovascular Surgery, Surgical Research Center and Plateform Nutrition Antioxydante et Santé, University Hospital of Liège, Liège, Belgium
- Jean-Paul Cheramy-Bien
- Department of Cardiovascular Surgery, Surgical Research Center and Plateform Nutrition Antioxydante et Santé, University Hospital of Liège, Liège, Belgium
- Thierry Huby, PhD
- INSERM UMR_S 1166, Integrative Biology of Atherosclerosis Team, Université Pierre et Marie Curie-Paris 6 and Institute of Cardiometabolism and Nutrition, Pitié-Salpêtrière Hospital, Paris, France
- Martin Giera, PhD
- Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands
- Bernhard Gerber, MD, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
- Anne-Catherine Pouleur, MD, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
- Bruno Guigas, PhD
- Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands
- Jean-Louis Vanoverschelde, MD, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
- Joelle Kefer, MD, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
- Luc Bertrand, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Cécile Oury, PhD
- Laboratory of Thrombosis and Hemostasis, GIGA-Cardiovascular Sciences, Department of Cardiology, Université de Liège, Liège, Belgium
- Sandrine Horman, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium
- Christophe Beauloye, MD, PhD
- Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; Division of Cardiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Address for correspondence: Dr. Christophe Beauloye, Division of Cardiology, Cliniques Universitaires Saint-Luc, Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Avenue Hippocrate, 55 (B1.55.05), 1200 Brussels, Belgium.
- Journal volume & issue
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Vol. 4,
no. 5
pp. 596 – 610
Abstract
Summary: Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK–induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK–induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function. Key Words: AMPK, acetyl-CoA carboxylase, coronary artery disease, lipidomics, platelet
