Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Samuela Cataldi; Cataldo Arcuri; Stéphane Hunot; François-Pierre Légeron; Carmen Mecca; Mercedes Garcia-Gil; Andrea Lazzarini; Michela Codini; Tommaso Beccari; Anna Tasegian; Bernard Fioretti; Giovanna Traina; Francesco Saverio Ambesi-Impiombato; Francesco Curcio; Elisabetta Albi

doi:10.1155/2017/2470950

Mediators of Inflammation (Jan 2017)

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Samuela Cataldi,
Cataldo Arcuri,
Stéphane Hunot,
François-Pierre Légeron,
Carmen Mecca,
Mercedes Garcia-Gil,
Andrea Lazzarini,
Michela Codini,
Tommaso Beccari,
Anna Tasegian,
Bernard Fioretti,
Giovanna Traina,
Francesco Saverio Ambesi-Impiombato,
Francesco Curcio,
Elisabetta Albi

Affiliations

Samuela Cataldi: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy
Cataldo Arcuri: Department of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy
Stéphane Hunot: Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelleépinière (ICM), 75013 Paris, France
François-Pierre Légeron: Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelleépinière (ICM), 75013 Paris, France
Carmen Mecca: Department of Experimental Medicine, University of Perugia, Polo Unico Sant’Andrea delle Fratte, Piazzale Gambuli, 06132 Perugia, Italy
Mercedes Garcia-Gil: Department of Biology and Interdepartmental Research Center Nutrafood “Nutraceuticals and Food for Health”, University of Pisa, Pisa, Italy
Andrea Lazzarini: CRABiON-Perugia, Via Ponchielli 4, 06073 Perugia, Italy
Michela Codini: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy
Tommaso Beccari: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy
Anna Tasegian: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy
Bernard Fioretti: Department of Chemistry, Biology and Biotechnology, Via Elce di sotto, 06123 Perugia, Italy
Giovanna Traina: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy
Francesco Saverio Ambesi-Impiombato: Dipartimento di Area Medica (DAME), University of Udine, P.le M. Kolbe 4, 33100 Udine, Italy
Francesco Curcio: Dipartimento di Area Medica (DAME), University of Udine, P.le M. Kolbe 4, 33100 Udine, Italy
Elisabetta Albi: Department of Pharmaceutical Science, University of Perugia, Perugia, Italy

DOI: https://doi.org/10.1155/2017/2470950
Journal volume & issue: Vol. 2017

Abstract

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Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the hippocampus during Parkinson’s disease remains undetected. In this study, we show an upregulation of inducible nitric oxide synthase and a downregulation of neutral sphingomyelinase in the hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced mouse model of Parkinson’s disease. Moreover, the stimulation of neutral sphingomyelinase activity with vitamin 1,25-dihydroxyvitamin D3 reduces specifically saturated fatty acid sphingomyelin by making sphingomyelin a less rigid molecule that might influence neurite plasticity. The possible biological relevance of the increase of neutral sphingomyelinase in Parkinson’s disease is discussed.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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