Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

Ishwarya Sankaranarayanan; Diana Tavares-Ferreira; Juliet M. Mwirigi; Galo L. Mejia; Michael D. Burton; Theodore J. Price

doi:10.1186/s12974-023-02719-8

Journal of Neuroinflammation (Feb 2023)

Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

Ishwarya Sankaranarayanan,
Diana Tavares-Ferreira,
Juliet M. Mwirigi,
Galo L. Mejia,
Michael D. Burton,
Theodore J. Price

Affiliations

Ishwarya Sankaranarayanan: Pain Neurobiology Research Group, University of Texas at Dallas
Diana Tavares-Ferreira: Pain Neurobiology Research Group, University of Texas at Dallas
Juliet M. Mwirigi: Pain Neurobiology Research Group, University of Texas at Dallas
Galo L. Mejia: Pain Neurobiology Research Group, University of Texas at Dallas
Michael D. Burton: Neuroimmunology and Behavior Laboratory, Department of Neuroscience, Center for Advanced Pain Studies, School of Behavioral and Brain Sciences, University of Texas at Dallas
Theodore J. Price: Pain Neurobiology Research Group, University of Texas at Dallas

DOI: https://doi.org/10.1186/s12974-023-02719-8
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 15

Abstract

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Highlights ICOS agonist antibody (ICOSaa) promotes paclitaxel-evoked pain resolution in female mice. DRG T cells appear to enter an anti-inflammatory phenotype by ICOSaa treatment. ICOSaa treatment increases DRG levels of IL-10 cytokine. ICOSaa effects in female mice are blocked by IL-10 sequestering treatment.

Published in Journal of Neuroinflammation

ISSN: 1742-2094 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://jneuroinflammation.biomedcentral.com/

About the journal

Abstract

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