Nature Communications (Jun 2016)
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
- Solene M. Evrard,
- Laura Lecce,
- Katherine C. Michelis,
- Aya Nomura-Kitabayashi,
- Gaurav Pandey,
- K-Raman Purushothaman,
- Valentina d’Escamard,
- Jennifer R. Li,
- Lahouaria Hadri,
- Kenji Fujitani,
- Pedro R. Moreno,
- Ludovic Benard,
- Pauline Rimmele,
- Ariella Cohain,
- Brigham Mecham,
- Gwendalyn J. Randolph,
- Elizabeth G. Nabel,
- Roger Hajjar,
- Valentin Fuster,
- Manfred Boehm,
- Jason C. Kovacic
Affiliations
- Solene M. Evrard
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Laura Lecce
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Katherine C. Michelis
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Aya Nomura-Kitabayashi
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Gaurav Pandey
- Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- K-Raman Purushothaman
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Valentina d’Escamard
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Jennifer R. Li
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Lahouaria Hadri
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Kenji Fujitani
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Pedro R. Moreno
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Ludovic Benard
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Pauline Rimmele
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Ariella Cohain
- Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Brigham Mecham
- Trialomics LLC
- Gwendalyn J. Randolph
- Department of Pathology and Immunology, Washington University
- Elizabeth G. Nabel
- Brigham and Women’s Health Care
- Roger Hajjar
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Valentin Fuster
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Manfred Boehm
- Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health
- Jason C. Kovacic
- The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/ncomms11853
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Endothelial to mesenchymal transition (EndMT) is a crucial developmental process that also plays a role in the pathogenesis of some diseases. Here the authors show that EndMT contributes to the development of atherosclerosis in mice and humans, and is associated with complex human plaques that may be prone to rupture.
