Frontiers in Public Health (Mar 2022)
The Incidence and Characteristics of Perinatal Stroke in Beijing: A Multicenter Study
- Qianqian Xia,
- Zhao Yang,
- Yao Xie,
- Ying Zhu,
- Zixin Yang,
- Mingyan Hei,
- Yingxue Ding,
- Weijing Kong,
- Limin Kang,
- Shengnan Yang,
- Yabo Mei,
- Zhichun Feng,
- Li Zhang,
- Yanzhe Lei,
- Ping Wang,
- Jingyu Dong,
- Li Yang,
- Jun Ju,
- Hesheng Chang,
- Shina Zhan,
- Jinqian Yu,
- Peng Zhang,
- Ran Wang,
- Hui Guo,
- Xinli Liu,
- Huaqing Tan,
- Yakun Liu,
- Zhenzong Zhang,
- Lixia Zhen,
- Jinting Yan,
- Zhan Liu,
- Chunxia Yang,
- Qingqing Wang,
- Jinfeng Wang,
- Lifang Sun,
- Huihui Zeng,
- Jing Li,
- Wenwen Qu,
- Xuemei Wang,
- Xuemei Wang,
- Guiying Liu,
- Xi Yang,
- Xinxin Liu,
- Xuefeng Zhang,
- Xiaojing Xu,
- Yanan Gu,
- Hui Long,
- Li Zhang,
- Lili Liu,
- Zezhong Tang,
- Xinlin Hou
Affiliations
- Qianqian Xia
- Pediatric Department, Peking University First Hospital, Beijing, China
- Zhao Yang
- Pediatric Department, Peking University First Hospital, Beijing, China
- Yao Xie
- Pediatric Department, Peking University First Hospital, Beijing, China
- Ying Zhu
- Pediatric Department, Peking University First Hospital, Beijing, China
- Zixin Yang
- Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
- Mingyan Hei
- Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China
- Yingxue Ding
- Beijing Friendship Hospital, Capital Medical University, Beijing, China
- Weijing Kong
- Beijing Friendship Hospital, Capital Medical University, Beijing, China
- Limin Kang
- Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China
- Shengnan Yang
- Department of Neonatology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China
- Yabo Mei
- Neonatal Intensive Care Unit of Faculty of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Zhichun Feng
- Neonatal Intensive Care Unit of Faculty of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Li Zhang
- Pediatric Department, Haidian Maternal and Child Health Hospital, Beijing, China
- Yanzhe Lei
- Pediatric Department, Haidian Maternal and Child Health Hospital, Beijing, China
- Ping Wang
- Department of Neonatology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
- Jingyu Dong
- Pediatric Department, Tongzhou Maternal and Child Health Hospital, Beijing, China
- Li Yang
- Pediatric Department, Tongzhou Maternal and Child Health Hospital, Beijing, China
- Jun Ju
- Pediatric Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Hesheng Chang
- Pediatric Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
- Shina Zhan
- 0Pediatric Department, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing, China
- Jinqian Yu
- 0Pediatric Department, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing, China
- Peng Zhang
- 1Pediatric Department, Beijing Miyun Maternal and Child Health Hospital, Beijing, China
- Ran Wang
- 1Pediatric Department, Beijing Miyun Maternal and Child Health Hospital, Beijing, China
- Hui Guo
- 2Pediatric Department, Fengtai Maternal and Child Health Hospital, Beijing, China
- Xinli Liu
- 2Pediatric Department, Fengtai Maternal and Child Health Hospital, Beijing, China
- Huaqing Tan
- 3Pediatric Department, Beijing Daxing Maternal and Child Care Hospital, Beijing, China
- Yakun Liu
- 3Pediatric Department, Beijing Daxing Maternal and Child Care Hospital, Beijing, China
- Zhenzong Zhang
- 4Pediatric Department, The First Hospital of Fangshan, Beijing, China
- Lixia Zhen
- 4Pediatric Department, The First Hospital of Fangshan, Beijing, China
- Jinting Yan
- 5Pediatric Department, Beijing Mentougou Hospital, Beijing, China
- Zhan Liu
- 5Pediatric Department, Beijing Mentougou Hospital, Beijing, China
- Chunxia Yang
- 6Pediatric Department, Changping Women and Children Health Care Hospital, Beijing, China
- Qingqing Wang
- 6Pediatric Department, Changping Women and Children Health Care Hospital, Beijing, China
- Jinfeng Wang
- 7Beijing Pinggu Maternal and Child Health Hospital, Beijing, China
- Lifang Sun
- 7Beijing Pinggu Maternal and Child Health Hospital, Beijing, China
- Huihui Zeng
- 8Pediatric Department, Huairou Maternal and Child Health Care Hospital, Beijing, China
- Jing Li
- 8Pediatric Department, Huairou Maternal and Child Health Care Hospital, Beijing, China
- Wenwen Qu
- 9Department of Pediatrics, Peking University Shougang Hospital and Capital Medical University, Beijing, China
- Xuemei Wang
- 9Department of Pediatrics, Peking University Shougang Hospital and Capital Medical University, Beijing, China
- Xuemei Wang
- 0General Respiratory Department of Beijing Jingdu Children's Hospital, Beijing, China
- Guiying Liu
- 1Department of Pediatrics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
- Xi Yang
- 1Department of Pediatrics, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
- Xinxin Liu
- 2Pediatric Department, Fifth Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Xuefeng Zhang
- 2Pediatric Department, Fifth Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Xiaojing Xu
- 3Pediatric Department, The First Hospital of Tsinghua University, Beijing, China
- Yanan Gu
- 3Pediatric Department, The First Hospital of Tsinghua University, Beijing, China
- Hui Long
- 4Department of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Li Zhang
- 4Department of Pediatrics, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China
- Lili Liu
- Pediatric Department, Peking University First Hospital, Beijing, China
- Zezhong Tang
- Pediatric Department, Peking University First Hospital, Beijing, China
- Xinlin Hou
- Pediatric Department, Peking University First Hospital, Beijing, China
- DOI
- https://doi.org/10.3389/fpubh.2022.783153
- Journal volume & issue
-
Vol. 10
Abstract
ObjectiveTo assess the incidence, risk factors, and clinical characteristics of perinatal stroke in Beijing.MethodsThis multicenter prospective study included all the live births from 17 representative maternal delivery hospitals in Beijing from March 1, 2019 to February 29, 2020. Neonates with a stroke were assigned to the study group. Clinical data, including general information, clinical manifestations, and risk factors, were collected. Up until 18 months after birth, neonates were routinely assessed according to the Ages and Stages Questionnaire (ASQ) and/or the Bayley scale. Statistical analysis was done using the chi-squared, t-tests, and logistic regression analysis using SPSS version 26.0.OutcomesIn total, 27 cases were identified and the incidence of perinatal stroke in Beijing was 1/2,660 live births, including 1/5,985 for ischemic stroke and 1/4,788 for hemorrhagic stroke. Seventeen cases (62.96%) of acute symptomatic stroke and convulsions within 72 h (10 cases, 37.04%) were the most common presentations. Ten patients showed no neurological symptoms and were found to have had a stroke through routine cranial ultrasonography after being hospitalized for non-neurological diseases. The risk factors include primiparity, placental or uterine abruption/acute chorioamnionitis, intrauterine distress, asphyxia, and severe infection. In the study group, 11.1% (3/27) of patients had adverse neurodevelopmental outcomes. The patients in the study group had lower scores for the ASQ than those in the control group in the communication, gross, and fine motor dimensions.ConclusionThe incidence of perinatal stroke in Beijing was consistent with that in other countries. Routine neuroimaging of infants with risk factors may enable identification of asymptomatic strokes in more patients. Patients who have suffered from a stroke may have neurological sequelae; therefore, early detection, treatment, and regular follow-ups are beneficial for improving their recovery outcomes.
Keywords
