Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease

Guillermo Gervasini; Zoraida Verde; Luz M. González; Celia Chicharro; Laura González-Rodríguez; Ana Fernández-Araque; Sonia Mota-Zamorano; Bárbara Cancho; Alberto Pérez-Hernández; Virginio García-López; Fernando Bandrés; Nicolás R. Robles

doi:10.3390/biomedicines11102775

Biomedicines (Oct 2023)

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease

Guillermo Gervasini,
Zoraida Verde,
Luz M. González,
Celia Chicharro,
Laura González-Rodríguez,
Ana Fernández-Araque,
Sonia Mota-Zamorano,
Bárbara Cancho,
Alberto Pérez-Hernández,
Virginio García-López,
Fernando Bandrés,
Nicolás R. Robles

Affiliations

Guillermo Gervasini: Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain
Zoraida Verde: Department of Biochemistry, Molecular Biology and Physiology, Universidad de Valladolid, 42005 Soria, Spain
Luz M. González: Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain
Celia Chicharro: Research Group Centro de Estudios Gregorio Marañón, Fundación Ortega-Marañón, 28010 Madrid, Spain
Laura González-Rodríguez: Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain
Ana Fernández-Araque: GIR—Pharmacogenetics, Cancer Genetics, Genetic Polymorphisms and Pharmacoepidemiology, University of Valladolid, 47005 Valladolid, Spain
Sonia Mota-Zamorano: Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain
Bárbara Cancho: Service of Nephrology, Badajoz University Hospital, 06006 Badajoz, Spain
Alberto Pérez-Hernández: Department of Clinical Biochemistry, Hospital Santa Bárbara, 42005 Soria, Spain
Virginio García-López: Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, 06006 Badajoz, Spain
Fernando Bandrés: Research Group Centro de Estudios Gregorio Marañón, Fundación Ortega-Marañón, 28010 Madrid, Spain
Nicolás R. Robles: RICORS2040 Renal Research Network, 28029 Madrid, Spain

DOI: https://doi.org/10.3390/biomedicines11102775
Journal volume & issue: Vol. 11, no. 10
p. 2775

Abstract

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There is a pressing need for more precise biomarkers of chronic kidney disease (CKD). Plasma samples from 820 subjects [231 with CKD, 325 with end-stage kidney disease (ESKD) and 264 controls] were analyzed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) to determine a metabolic profile of 28 amino acids (AAs) and biogenic amines to test their value as markers of CKD risk and progression. The kynurenine/tryptophan ratio showed the strongest correlation with estimated glomerular filtration rate values (coefficient = −0.731, p p p p p < 0.0001). Plasma concentrations of AAs and related amines may be useful as diagnostic biomarkers of kidney disease, both for CKD risk and for progression of CKD patients to ESKD.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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