Frontiers in Neuroscience (Aug 2022)

CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder

  • Tianlin Jiang,
  • Yanli Wang,
  • Xiaohong Wang,
  • Xiaohong Wang,
  • Xiaohong Wang,
  • Jun Xu

DOI
https://doi.org/10.3389/fnins.2022.988265
Journal volume & issue
Vol. 16

Abstract

Read online

CHCHD2 and CHCHD10 are homolog mitochondrial proteins that play key roles in the neurological, cardiovascular, and reproductive systems. They are also involved in the mitochondrial metabolic process. Although previous research has concentrated on their functions within mitochondria, their functions within apoptosis, synaptic plasticity, cell migration as well as lipid metabolism remain to be concluded. The review highlights the different roles played by CHCHD2 and/or CHCHD10 binding to various target proteins (such as OPA-1, OMA-1, PINK, and TDP43) and reveals their non-negligible effects in cognitive impairments and motor neuron diseases. This review focuses on the functions of CHCHD2 and/or CHCHD10. This review reveals protective effects and mechanisms of CHCHD2 and CHCHD10 in neurodegenerative diseases characterized by cognitive and motor deficits, such as frontotemporal dementia (FTD), Lewy body dementia (LBD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). However, there are numerous specific mechanisms that have yet to be elucidated, and additional research into these mechanisms is required.

Keywords