PEGylated graphene oxide elicits strong immunological responses despite surface passivation

Nana Luo; Jeffrey K. Weber; Shuang Wang; Binquan Luan; Hua Yue; Xiaobo Xi; Jing Du; Zaixing Yang; Wei Wei; Ruhong Zhou; Guanghui Ma

doi:10.1038/ncomms14537

Nature Communications (Feb 2017)

PEGylated graphene oxide elicits strong immunological responses despite surface passivation

Nana Luo,
Jeffrey K. Weber,
Shuang Wang,
Binquan Luan,
Hua Yue,
Xiaobo Xi,
Jing Du,
Zaixing Yang,
Wei Wei,
Ruhong Zhou,
Guanghui Ma

Affiliations

Nana Luo: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Jeffrey K. Weber: Computational Biology Center, IBM Thomas J. Watson Research Center
Shuang Wang: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Binquan Luan: Computational Biology Center, IBM Thomas J. Watson Research Center
Hua Yue: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Xiaobo Xi: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Jing Du: Department of Engineering Mechanics, Institute of Biomechanics and Medical Engineering, Tsinghua University
Zaixing Yang: Institute of Quantitative Biology and Medicine, SRMP and RAD-X, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University
Wei Wei: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
Ruhong Zhou: Computational Biology Center, IBM Thomas J. Watson Research Center
Guanghui Ma: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms14537
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Polyethylene glycol has been widely utilized to functionalize nanomaterials in order to improve their biocompatibility. Here, the authors demonstrate that PEGylated nano-graphene oxide can elicit an inflammatory response, contradicting current literature.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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