Nature Communications (Nov 2022)
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
- Matthew R. Stutz,
- Nicholas P. Dylla,
- Steven D. Pearson,
- Paola Lecompte-Osorio,
- Ravi Nayak,
- Maryam Khalid,
- Emerald Adler,
- Jaye Boissiere,
- Huaiying Lin,
- William Leiter,
- Jessica Little,
- Amber Rose,
- David Moran,
- Michael W. Mullowney,
- Krysta S. Wolfe,
- Christopher Lehmann,
- Matthew Odenwald,
- Mark De La Cruz,
- Mihai Giurcanu,
- Anne S. Pohlman,
- Jesse B. Hall,
- Jean-Luc Chaubard,
- Anitha Sundararajan,
- Ashley Sidebottom,
- John P. Kress,
- Eric G. Pamer,
- Bhakti K. Patel
Affiliations
- Matthew R. Stutz
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Nicholas P. Dylla
- Duchossois Family Institute, University of Chicago
- Steven D. Pearson
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Paola Lecompte-Osorio
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Ravi Nayak
- Duchossois Family Institute, University of Chicago
- Maryam Khalid
- Duchossois Family Institute, University of Chicago
- Emerald Adler
- Duchossois Family Institute, University of Chicago
- Jaye Boissiere
- Duchossois Family Institute, University of Chicago
- Huaiying Lin
- Duchossois Family Institute, University of Chicago
- William Leiter
- Duchossois Family Institute, University of Chicago
- Jessica Little
- Duchossois Family Institute, University of Chicago
- Amber Rose
- Duchossois Family Institute, University of Chicago
- David Moran
- Duchossois Family Institute, University of Chicago
- Michael W. Mullowney
- Duchossois Family Institute, University of Chicago
- Krysta S. Wolfe
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Christopher Lehmann
- Department of Medicine, Section of Infectious Diseases & Global Health, University of Chicago Medicine
- Matthew Odenwald
- Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine
- Mark De La Cruz
- Department of Medicine, Section of Cardiology, University of Chicago Medicine
- Mihai Giurcanu
- Biological Sciences Division, Biostatistics Laboratory & Research Computing Group, University of Chicago
- Anne S. Pohlman
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Jesse B. Hall
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Jean-Luc Chaubard
- Duchossois Family Institute, University of Chicago
- Anitha Sundararajan
- Duchossois Family Institute, University of Chicago
- Ashley Sidebottom
- Duchossois Family Institute, University of Chicago
- John P. Kress
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- Eric G. Pamer
- Duchossois Family Institute, University of Chicago
- Bhakti K. Patel
- Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34260-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Here, via applying metagenomics and metabolomics analyses, the authors show that fecal microbiota composition and microbiota-derived metabolites predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection, suggesting the gut-lung axis to play an important role in the recovery from COVID-19.
