Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

Serena Governali; Marco Caremani; Cristina Gallart; Irene Pertici; Ger Stienen; Gabriella Piazzesi; Coen Ottenheijm; Vincenzo Lombardi; Marco Linari

doi:10.1038/s41467-020-17143-2

Nature Communications (Jul 2020)

Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

Serena Governali,
Marco Caremani,
Cristina Gallart,
Irene Pertici,
Ger Stienen,
Gabriella Piazzesi,
Coen Ottenheijm,
Vincenzo Lombardi,
Marco Linari

Affiliations

Serena Governali: PhysioLab, Department of Biology, University of Florence
Marco Caremani: PhysioLab, Department of Biology, University of Florence
Cristina Gallart: PhysioLab, Department of Biology, University of Florence
Irene Pertici: PhysioLab, Department of Biology, University of Florence
Ger Stienen: Department of Physiology, Amsterdam UMC (location VUmc)
Gabriella Piazzesi: PhysioLab, Department of Biology, University of Florence
Coen Ottenheijm: Department of Physiology, Amsterdam UMC (location VUmc)
Vincenzo Lombardi: PhysioLab, Department of Biology, University of Florence
Marco Linari: PhysioLab, Department of Biology, University of Florence

DOI: https://doi.org/10.1038/s41467-020-17143-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Omecamtiv mecarbil is a small molecule effector under clinical trial for the treatment of systolic heart failure. Here the authors define the molecular mechanisms of its inotropic action and find it can increase the efficiency of contraction in muscle fibres when the orthophosphate concentration rises with the beat frequency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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