LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

Pingping Zhu; Yanying Wang; Jiayi Wu; Guanling Huang; Benyu Liu; Buqing Ye; Ying Du; Guangxia Gao; Yong Tian; Lei He; Zusen Fan

doi:10.1038/ncomms13608

Nature Communications (Dec 2016)

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

Pingping Zhu,
Yanying Wang,
Jiayi Wu,
Guanling Huang,
Benyu Liu,
Buqing Ye,
Ying Du,
Guangxia Gao,
Yong Tian,
Lei He,
Zusen Fan

Affiliations

Pingping Zhu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yanying Wang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jiayi Wu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Guanling Huang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Benyu Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Buqing Ye: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Ying Du: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Guangxia Gao: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yong Tian: Key Laboratory of RNA Biology and Beijing Noncoding RNA Laboratory, Institute of Biophysics, Chinese Academy of Sciences
Lei He: Department of Hepatobiliary Surgery, PLA General Hospital
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms13608
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence of hepatocellular carcinoma. Here, the authors show that the long coding RNA, LcnBRM, regulates the self-renewal of liver CSCs and tumour initiation through binding to BAF complex thereby activating YAP1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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