Nature Communications (Apr 2021)

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

  • Alexander Beatty,
  • Tanu Singh,
  • Yulia Y. Tyurina,
  • Vladimir A. Tyurin,
  • Svetlana Samovich,
  • Emmanuelle Nicolas,
  • Kristen Maslar,
  • Yan Zhou,
  • Kathy Q. Cai,
  • Yinfei Tan,
  • Sebastian Doll,
  • Marcus Conrad,
  • Aravind Subramanian,
  • Hülya Bayır,
  • Valerian E. Kagan,
  • Ulrike Rennefahrt,
  • Jeffrey R. Peterson

DOI
https://doi.org/10.1038/s41467-021-22471-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Inhibition of the lipid peroxidase GPX4 promotes ferroptotic cell death. Here, the authors identify a complementary approach using conjugated linolenic fatty acids that trigger lipid peroxidation and ferroptosis via ACSL1, DGAT1/2, and neutral lipids.