Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Jiangqing Dong; Ximing Du; Huan Wang; Jue Wang; Chang Lu; Xiang Chen; Zhiwen Zhu; Zhipu Luo; Li Yu; Andrew J. Brown; Hongyuan Yang; Jia-Wei Wu

doi:10.1038/s41467-019-08791-0

Nature Communications (Feb 2019)

Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2

Jiangqing Dong,
Ximing Du,
Huan Wang,
Jue Wang,
Chang Lu,
Xiang Chen,
Zhiwen Zhu,
Zhipu Luo,
Li Yu,
Andrew J. Brown,
Hongyuan Yang,
Jia-Wei Wu

Affiliations

Jiangqing Dong: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Ximing Du: School of Biotechnology and Biomolecular Sciences, the University of New South Wales
Huan Wang: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Jue Wang: Institute of Molecular Enzymology, Soochow University
Chang Lu: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Xiang Chen: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Zhiwen Zhu: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Zhipu Luo: Institute of Molecular Enzymology, Soochow University
Li Yu: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Andrew J. Brown: School of Biotechnology and Biomolecular Sciences, the University of New South Wales
Hongyuan Yang: School of Biotechnology and Biomolecular Sciences, the University of New South Wales
Jia-Wei Wu: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory for Protein Science, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University

DOI: https://doi.org/10.1038/s41467-019-08791-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P2/PI(3,4)P2 allosterically enhances ORP1-mediated cholesterol exit from LELs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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