Nature Communications (Jun 2022)
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
- Brandon M. Murphy,
- Elizabeth M. Terrell,
- Venkat R. Chirasani,
- Tirzah J. Weiss,
- Rachel E. Lew,
- Andrea M. Holderbaum,
- Aastha Dhakal,
- Valentina Posada,
- Marie Fort,
- Michael S. Bodnar,
- Leiah M. Carey,
- Min Chen,
- Craig J. Burd,
- Vincenzo Coppola,
- Deborah K. Morrison,
- Sharon L. Campbell,
- Christin E. Burd
Affiliations
- Brandon M. Murphy
- Department of Cancer Biology and Genetics, The Ohio State University
- Elizabeth M. Terrell
- Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
- Venkat R. Chirasani
- Department of Biochemistry & Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Tirzah J. Weiss
- Department of Cancer Biology and Genetics, The Ohio State University
- Rachel E. Lew
- Department of Cancer Biology and Genetics, The Ohio State University
- Andrea M. Holderbaum
- Department of Cancer Biology and Genetics, The Ohio State University
- Aastha Dhakal
- Department of Molecular Genetics, The Ohio State University
- Valentina Posada
- Department of Molecular Genetics, The Ohio State University
- Marie Fort
- Department of Molecular Genetics, The Ohio State University
- Michael S. Bodnar
- Department of Cancer Biology and Genetics, The Ohio State University
- Leiah M. Carey
- Department of Biochemistry & Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Min Chen
- Department of Cancer Biology and Genetics, The Ohio State University
- Craig J. Burd
- Department of Molecular Genetics, The Ohio State University
- Vincenzo Coppola
- Department of Cancer Biology and Genetics, The Ohio State University
- Deborah K. Morrison
- Laboratory of Cell and Developmental Signaling, National Cancer Institute-Frederick
- Sharon L. Campbell
- Department of Biochemistry & Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Christin E. Burd
- Department of Cancer Biology and Genetics, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-022-30881-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of specific NRAS mutants in human melanoma
