PLoS ONE (Jan 2021)

Acute kidney injury and acute kidney recovery following Transcatheter Aortic Valve Replacement

  • Marilou Peillex,
  • Benjamin Marchandot,
  • Kensuke Matsushita,
  • Eric Prinz,
  • Sebastien Hess,
  • Antje Reydel,
  • Marion Kibler,
  • Adrien Carmona,
  • Antonin Trimaille,
  • Joe Heger,
  • Hélène Petit-Eisenmann,
  • Annie Trinh,
  • Laurence Jesel,
  • Patrick Ohlmann,
  • Olivier Morel

Journal volume & issue
Vol. 16, no. 8

Abstract

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Background Acute kidney injury (AKI) is associated with a dismal prognosis in Transcatheter Aortic Valve replacement (TAVR). Acute kidney recovery (AKR), a phenomenon reverse to AKI has recently been associated with better outcomes. Methods Between November 2012 to May 2018, we explored consecutive patients referred to our Heart Valve Center for TAVR. AKI was defined according to the VARC-2 definition. Mirroring the VARC-2 definition of AKI, AKR was defined as a decrease in serum creatinine (≥50%) or ≥25% improvement in GFR up to 72 hours after TAVR. Results AKI and AKR were respectively observed in 8.3 and 15.7% of the 574 patients included. AKI and AKR patients were associated to more advanced kidney disease at baseline. At a median follow-up of 608 days (range 355–893), AKI and AKR patients experienced an increased cardiovascular mortality compared to unchanged renal function patients (14.6% and 17.8% respectively, vs. 8.1%, CI 95%, pConclusions Both AKR and AKI negatively impact long term clinical outcomes of patients undergoing TAVR.