Lamotrigine‐induced neutropenia after high‐dose concomitant initiation with phenytoin

Abstract

Abstract Lamotrigine has been repeatedly reported to cause hematologic toxicities, which may be associated with high initial doses or excessive escalation. A 29‐year‐old lady experienced profound neutropenia after two weeks of lamotrigine high initial dose, started within two days of phenytoin. The too‐early dose intensification may have produced lamotrigine‐induced blood dyscrasia.

Keywords

• lamotrigine
• leucopenia
• neutropenia
• phenytoin
• UGT1A4