Nature Communications (Mar 2023)
The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation
- Markus Meier,
- Monika Gupta,
- Serife Akgül,
- Matthew McDougall,
- Thomas Imhof,
- Denise Nikodemus,
- Raphael Reuten,
- Aniel Moya-Torres,
- Vu To,
- Fraser Ferens,
- Fabian Heide,
- Gay Pauline Padilla-Meier,
- Philipp Kukura,
- Wenming Huang,
- Birgit Gerisch,
- Matthias Mörgelin,
- Kate Poole,
- Adam Antebi,
- Manuel Koch,
- Jörg Stetefeld
Affiliations
- Markus Meier
- Department of Chemistry, University of Manitoba
- Monika Gupta
- Department of Chemistry, University of Manitoba
- Serife Akgül
- Center for Biochemistry II, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Matthew McDougall
- Department of Chemistry, University of Manitoba
- Thomas Imhof
- Center for Biochemistry II, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Denise Nikodemus
- Faculty of Biology, Institute of Biology II, Albert Ludwigs University of Freiburg
- Raphael Reuten
- Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg
- Aniel Moya-Torres
- Department of Chemistry, University of Manitoba
- Vu To
- Department of Chemistry, University of Manitoba
- Fraser Ferens
- Department of Chemistry, University of Manitoba
- Fabian Heide
- Department of Chemistry, University of Manitoba
- Gay Pauline Padilla-Meier
- Department of Chemistry, University of Manitoba
- Philipp Kukura
- Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford
- Wenming Huang
- Max Planck Institute for Biology of Ageing
- Birgit Gerisch
- Max Planck Institute for Biology of Ageing
- Matthias Mörgelin
- Colzyx AB
- Kate Poole
- Max Delbrück Center for Molecular Medicine
- Adam Antebi
- Max Planck Institute for Biology of Ageing
- Manuel Koch
- Center for Biochemistry II, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Jörg Stetefeld
- Department of Chemistry, University of Manitoba
- DOI
- https://doi.org/10.1038/s41467-023-36692-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.
