NeuroImage: Clinical (Jan 2021)
Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer’s disease
- Jennifer Tremblay-Mercier,
- Cécile Madjar,
- Samir Das,
- Alexa Pichet Binette,
- Stephanie O.M. Dyke,
- Pierre Étienne,
- Marie-Elyse Lafaille-Magnan,
- Jordana Remz,
- Pierre Bellec,
- D. Louis Collins,
- M. Natasha Rajah,
- Veronique Bohbot,
- Jeannie-Marie Leoutsakos,
- Yasser Iturria-Medina,
- Justin Kat,
- Richard D. Hoge,
- Serge Gauthier,
- Christine L. Tardif,
- M. Mallar Chakravarty,
- Jean-Baptiste Poline,
- Pedro Rosa-Neto,
- Alan C. Evans,
- Sylvia Villeneuve,
- Judes Poirier,
- John C.S. Breitner
Affiliations
- Jennifer Tremblay-Mercier
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada
- Cécile Madjar
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Samir Das
- McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Alexa Pichet Binette
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Stephanie O.M. Dyke
- McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Pierre Étienne
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Marie-Elyse Lafaille-Magnan
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; Centre for Child Development and Mental Health, Jewish General Hospital. Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Jordana Remz
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada
- Pierre Bellec
- CRIUGM - Université de Montréal, Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada
- D. Louis Collins
- McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- M. Natasha Rajah
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Veronique Bohbot
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Jeannie-Marie Leoutsakos
- John Hopkins University School of Medicine, Baltimore, MD, USA,
- Yasser Iturria-Medina
- McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Justin Kat
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Richard D. Hoge
- McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Serge Gauthier
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada
- Christine L. Tardif
- McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- M. Mallar Chakravarty
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Jean-Baptiste Poline
- McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
- Pedro Rosa-Neto
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montréal, QC, Canada
- Alan C. Evans
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Sylvia Villeneuve
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Judes Poirier
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada; Corresponding author at: 6875 boul. Lasalle, Montreal H4H 1R3, Canada.
- John C.S. Breitner
- StoP-AD Centre, Douglas Mental Health Institute Research Centre, Montréal, QC, Canada; McGill University, Montréal, QC, Canada
- Journal volume & issue
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Vol. 31
p. 102733
Abstract
To move Alzheimer Disease (AD) research forward it is essential to collect data from large cohorts, but also make such data available to the global research community. We describe the creation of an open science dataset from the PREVENT-AD (PResymptomatic EValuation of Experimental or Novel Treatments for AD) cohort, composed of cognitively unimpaired older individuals with a parental or multiple-sibling history of AD. From 2011 to 2017, 386 participants were enrolled (mean age 63 years old ± 5) for sustained investigation among whom 349 have retrospectively agreed to share their data openly. Repositories are findable through the unified interface of the Canadian Open Neuroscience Platform and contain up to five years of longitudinal imaging data, cerebral fluid biochemistry, neurosensory capacities, cognitive, genetic, and medical information. Imaging data can be accessed openly at https://openpreventad.loris.ca while most of the other information, sensitive by nature, is accessible by qualified researchers at https://registeredpreventad.loris.ca. In addition to being a living resource for continued data acquisition, PREVENT-AD offers opportunities to facilitate understanding of AD pathogenesis.
