Nature Communications (Jul 2022)
Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity
- Aimee M. Deaton,
- Aditi Dubey,
- Lucas D. Ward,
- Peter Dornbos,
- Jason Flannick,
- AMP-T2D-GENES Consortium,
- Elaine Yee,
- Simina Ticau,
- Leila Noetzli,
- Margaret M. Parker,
- Rachel A. Hoffing,
- Carissa Willis,
- Mollie E. Plekan,
- Aaron M. Holleman,
- Gregory Hinkle,
- Kevin Fitzgerald,
- Akshay K. Vaishnaw,
- Paul Nioi
Affiliations
- Aimee M. Deaton
- Alnylam Pharmaceuticals
- Aditi Dubey
- Alnylam Pharmaceuticals
- Lucas D. Ward
- Alnylam Pharmaceuticals
- Peter Dornbos
- Programs in Metabolism and Medical & Population Genetics, Broad Institute
- Jason Flannick
- Programs in Metabolism and Medical & Population Genetics, Broad Institute
- AMP-T2D-GENES Consortium
- Elaine Yee
- Alnylam Pharmaceuticals
- Simina Ticau
- Alnylam Pharmaceuticals
- Leila Noetzli
- Alnylam Pharmaceuticals
- Margaret M. Parker
- Alnylam Pharmaceuticals
- Rachel A. Hoffing
- Alnylam Pharmaceuticals
- Carissa Willis
- Alnylam Pharmaceuticals
- Mollie E. Plekan
- Alnylam Pharmaceuticals
- Aaron M. Holleman
- Alnylam Pharmaceuticals
- Gregory Hinkle
- Alnylam Pharmaceuticals
- Kevin Fitzgerald
- Alnylam Pharmaceuticals
- Akshay K. Vaishnaw
- Alnylam Pharmaceuticals
- Paul Nioi
- Alnylam Pharmaceuticals
- DOI
- https://doi.org/10.1038/s41467-022-31757-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Abdominal fat has been shown to increase cardiometabolic disease risk. In this study, the authors report that loss-of-function variants in the gene INHBE associate with lower BMI-adjusted waist-to-hip ratio, a surrogate measure of abdominal fat.
