IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice

Yangping Wang; Yang Bai; Yashu Li; Guangping Liang; Yufeng Jiang; Zhongyang Liu; Meixi Liu; Jianlei Hao; Xiaorong Zhang; Xiaorong Zhang; Xiaohong Hu; Xiaohong Hu; Jian Chen; Jian Chen; Rupeng Wang; Zhinan Yin; Jun Wu; Jun Wu; Gaoxing Luo; Gaoxing Luo; Weifeng He; Weifeng He

doi:10.3389/fimmu.2017.01557

Frontiers in Immunology (Nov 2017)

IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice

Yangping Wang,
Yang Bai,
Yashu Li,
Guangping Liang,
Yufeng Jiang,
Zhongyang Liu,
Meixi Liu,
Jianlei Hao,
Xiaorong Zhang,
Xiaorong Zhang,
Xiaohong Hu,
Xiaohong Hu,
Jian Chen,
Jian Chen,
Rupeng Wang,
Zhinan Yin,
Jun Wu,
Jun Wu,
Gaoxing Luo,
Gaoxing Luo,
Weifeng He,
Weifeng He

Affiliations

Yangping Wang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Yang Bai: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Yashu Li: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Guangping Liang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Yufeng Jiang: Wound Healing Center, Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China
Zhongyang Liu: Department of Plastic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Meixi Liu: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Jianlei Hao: Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Biomedical Translational Research Institute, Jinan University, Guangzhou, China
Xiaorong Zhang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Xiaorong Zhang: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Xiaohong Hu: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Xiaohong Hu: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Jian Chen: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Jian Chen: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Rupeng Wang: Department of Dermatology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China
Zhinan Yin: Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Biomedical Translational Research Institute, Jinan University, Guangzhou, China
Jun Wu: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Jun Wu: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Gaoxing Luo: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Gaoxing Luo: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Weifeng He: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, The Third Military Medical University, Chongqing, China
Weifeng He: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China

DOI: https://doi.org/10.3389/fimmu.2017.01557
Journal volume & issue: Vol. 8

Abstract

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Altered homeostasis and dysfunction of dendritic epidermal T cells (DETCs) contribute to abnormal diabetic wound healing. IL-15 plays important roles in survival and activation of T lymphocytes. Recently, reduction of epidermal IL-15 has been reported as an important mechanism for abnormal DETC homeostasis in streptozotocin -induced diabetic animals. However, the role of IL-15 in impaired diabetic wound healing remains unknown. Here, we found that, through rescuing the insufficient activation of DETCs, IL-15 increased IGF-1 production by DETCs and thereby promoted diabetic skin wound repair. Regulation of IGF-1 in DETCs by IL-15 was partly dependent on the mTOR pathway. In addition, expression of IL-15 and IGF-1 were positively correlated in wounded epidermis. Together, our data indicated that IL-15 enhanced IGF-1 production by DETCs to promoting diabetic wound repair, suggesting IL-15 as a potential therapeutic agent for managing diabetic wound healing.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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