One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline

Abstract

A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via the performance of one-pot Ugi-azide and Heck cyclization reactions. The integration of the multicomponent and post-condensation reactions in one-pot maximizes the pot-, atom-, and step-economy (PASE).

Keywords

• heck reaction
• one-pot
• tetrahydroisoquinoline
• tetrazolo-pyrazino[2,1-a]isoquinolin-6(5h)-ones
• tetrazole
• ugi-azide reaction