Nature Communications (Jul 2018)

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

  • Amit S. Joshi,
  • Benjamin Nebenfuehr,
  • Vineet Choudhary,
  • Prasanna Satpute-Krishnan,
  • Tim P. Levine,
  • Andy Golden,
  • William A. Prinz

DOI
https://doi.org/10.1038/s41467-018-05277-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Lipid droplets (LDs) and peroxisomes are both generated by budding off the endoplasmic reticulum (ER). Here, the authors show that the yeast protein Pex30 marks ER subdomains where both LD and peroxisome biogenesis occurs, and identify MCTP2 as the putative mammalian Pex30 ortholog.