Fia-Cl Determination of Paracetamol Using Luminol–Kmno4–Pb Post-Cl System, Applying Merging Zone Principle

Abstract

This paper reports a new and simple flow injection analysis (FIA) with post- chemiluminescence system (PCL) for determination of paracetamol through merging zone principle. The method was based on the inhibition of luminol–KMnO4–Pb post- chemiluminescence (PCL).Various parameters associated with this flow system were studied and essential optimizations were carried out. Calibration graph were constructed for determination of paracetamol in the range (5.0–30) μg.ml-1 with correlation coefficient (0.996) .The method was applied successfully for the determination of paracetamol in commercial pharmaceutical products.

Keywords

• post-Chemiluminescence
• flow injection analysis
• paracetamol