Nature Communications (Jul 2022)
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9
- Yongyao Fu,
- Abigail Pajulas,
- Jocelyn Wang,
- Baohua Zhou,
- Anthony Cannon,
- Cherry Cheuk Lam Cheung,
- Jilu Zhang,
- Huaxin Zhou,
- Amanda Jo Fisher,
- David T. Omstead,
- Sabrina Khan,
- Lei Han,
- Jean-Christophe Renauld,
- Sophie Paczesny,
- Hongyu Gao,
- Yunlong Liu,
- Lei Yang,
- Robert M. Tighe,
- Paula Licona-Limón,
- Richard A. Flavell,
- Shogo Takatsuka,
- Daisuke Kitamura,
- Jie Sun,
- Basar Bilgicer,
- Catherine R. Sears,
- Kai Yang,
- Mark H. Kaplan
Affiliations
- Yongyao Fu
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Abigail Pajulas
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Jocelyn Wang
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Baohua Zhou
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Anthony Cannon
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Cherry Cheuk Lam Cheung
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Jilu Zhang
- Department of Microbiology and Immunology, Indiana University School of Medicine
- Huaxin Zhou
- Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine
- Amanda Jo Fisher
- Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine
- David T. Omstead
- Department of Chemical and Biomolecular Engineering, University of Notre Dame
- Sabrina Khan
- Department of Chemical and Biomolecular Engineering, University of Notre Dame
- Lei Han
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Jean-Christophe Renauld
- Ludwig Institute for Cancer Research, Experimental Medicine Unit, Université Catholique de Louvain
- Sophie Paczesny
- Department of Microbiology and Immunology, Medical University of South Carolina
- Hongyu Gao
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Yunlong Liu
- Department of Medical and Molecular Genetics, Indiana University School of Medicine
- Lei Yang
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Robert M. Tighe
- Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center
- Paula Licona-Limón
- Departamento de Biologia Celular y del Desarrollo, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México
- Richard A. Flavell
- Department of Immunobiology, Yale University School of Medicine
- Shogo Takatsuka
- Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
- Daisuke Kitamura
- Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science
- Jie Sun
- Department of Medicine, Mayo Clinic
- Basar Bilgicer
- Department of Chemical and Biomolecular Engineering, University of Notre Dame
- Catherine R. Sears
- Division of Pulmonary, Critical Care, Sleep and Occupational Medicine/Department of Medicine, Indiana University School of Medicine
- Kai Yang
- Department of Pediatrics and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine
- Mark H. Kaplan
- Department of Microbiology and Immunology, Indiana University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31596-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
The role of IL-9 in the tumor microenvironment and its effects on macrophages remains unclear. Here, the authors show that IL-9 promotes the expansion of pulmonary macrophages and that targeting the IL-9R/arginase 1 axis restricts tumor growth, thus identifying this cytokine pathway as a potential therapeutic target.
