Nature Communications (Jun 2020)

The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis

  • Qikun Liu,
  • Sylvain Bischof,
  • C. Jake Harris,
  • Zhenhui Zhong,
  • Lingyu Zhan,
  • Calvin Nguyen,
  • Andrew Rashoff,
  • William D. Barshop,
  • Fei Sun,
  • Suhua Feng,
  • Magdalena Potok,
  • Javier Gallego-Bartolome,
  • Jixian Zhai,
  • James A. Wohlschlegel,
  • Michael F. Carey,
  • Jeffrey A. Long,
  • Steven E. Jacobsen

DOI
https://doi.org/10.1038/s41467-020-16651-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Mediator is a multiprotein complex required to activate gene transcription by RNAPII. Here, the authors report that MED12 and MED13 are conditional positive regulators that facilitate the expression of genes depleted in active chromatin marks and the induction of gene expression in response to environmental stimuli in Arabidopsis.