Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

Kerry J. Laing; Werner J. D. Ouwendijk; Victoria L. Campbell; Christopher L. McClurkan; Shahin Mortazavi; Michael Elder Waters; Maxwell P. Krist; Richard Tu; Nhi Nguyen; Krithi Basu; Congrong Miao; D. Scott Schmid; Christine Johnston; Georges M. G. M. Verjans; David M. Koelle

doi:10.1038/s41467-022-34698-4

Nature Communications (Nov 2022)

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

Kerry J. Laing,
Werner J. D. Ouwendijk,
Victoria L. Campbell,
Christopher L. McClurkan,
Shahin Mortazavi,
Michael Elder Waters,
Maxwell P. Krist,
Richard Tu,
Nhi Nguyen,
Krithi Basu,
Congrong Miao,
D. Scott Schmid,
Christine Johnston,
Georges M. G. M. Verjans,
David M. Koelle

Affiliations

Kerry J. Laing: Department of Medicine, University of Washington
Werner J. D. Ouwendijk: HerpeslabNL of the Department of Viroscience, Erasmus Medical Center
Victoria L. Campbell: Department of Medicine, University of Washington
Christopher L. McClurkan: Department of Medicine, University of Washington
Shahin Mortazavi: Department of Medicine, University of Washington
Michael Elder Waters: Department of Medicine, University of Washington
Maxwell P. Krist: Department of Medicine, University of Washington
Richard Tu: Department of Medicine, University of Washington
Nhi Nguyen: Department of Medicine, University of Washington
Krithi Basu: Department of Medicine, University of Washington
Congrong Miao: Centers for Disease Control and Prevention, Division of Viral Diseases
D. Scott Schmid: Centers for Disease Control and Prevention, Division of Viral Diseases
Christine Johnston: Department of Medicine, University of Washington
Georges M. G. M. Verjans: HerpeslabNL of the Department of Viroscience, Erasmus Medical Center
David M. Koelle: Department of Medicine, University of Washington

DOI: https://doi.org/10.1038/s41467-022-34698-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

T cells are considered important for controlling skin infections. Here, the authors report that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in rash-involved skin after recovery from zoster.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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