Prognostic significance of genetic factors in the development of proliferative diseases of the uterus

Abstract

Were studied reproductive health of 200 women aged from 18 to 48 years, of which 64 with fibroids, 33 - with fibroids in combination with adenomyosis and 103 - without fibroids and adenomyosis. Performed genotyping of six molecular genetic markers (SNPs-351A/G and -397 T/S ESRa gene, a polymorphic marker genes of tumor necrosis factor a receptor tumor necrosis factor 1-St and 2-nd type and lymphotoxin a) to study the role of family history in the formation of fibroids in the uterus in women. Women with genotypes GG, GA, AA polymorphism +36 A/G receptor tumor necrosis factor 1 and type GG polymorphism +250 G/A lymphotoxin a are increased risk of developing uterine fibroids and adenomyosis.

Keywords

• миома матки
• аденомиоз
• молекулярно-генетические маркеры
• uterine fibroids
• adenomyosis
• molecular genetic markers