Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging

Sidan Tian; Haozheng Li; Zhong Li; Huajun Tang; Mingming Yin; Yage Chen; Shun Wang; Yuting Gao; Xiangliang Yang; Fanling Meng; Joseph W. Lauher; Ping Wang; Liang Luo

doi:10.1038/s41467-019-13784-0

Nature Communications (Jan 2020)

Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging

Sidan Tian,
Haozheng Li,
Zhong Li,
Huajun Tang,
Mingming Yin,
Yage Chen,
Shun Wang,
Yuting Gao,
Xiangliang Yang,
Fanling Meng,
Joseph W. Lauher,
Ping Wang,
Liang Luo

Affiliations

Sidan Tian: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Haozheng Li: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
Zhong Li: Department of Chemistry, Stony Brook University
Huajun Tang: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
Mingming Yin: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Yage Chen: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
Shun Wang: MOE Key Laboratory of Fundamental Physical Quantities Measurement & Hubei Key Laboratory of Gravitation and Quantum Physics, PGMF and School of Physics, Huazhong University of Science and Technology
Yuting Gao: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Xiangliang Yang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Fanling Meng: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Joseph W. Lauher: Department of Chemistry, Stony Brook University
Ping Wang: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology
Liang Luo: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-13784-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Raman probes which operate in the cellular silent region are of interest for live cell imaging. Here, the authors report on the development of a water soluble polydiacetylene Raman probe with enhanced Raman signal in the silent region which can be functionalised for organelle targeting and demonstrate application.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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