Intravesical ALT-803 for BCG-unresponsive Bladder Cancer – A Case Report

Abstract

The administration of intravesical chemotherapy or BCG often can prolong the progression-free interval after initial transurethral resection in select bladder cancer (BCa) patients. However, 60% of these patients will recur and up to 30% of patients with recurrent BCa will progress and succumb to their disease over a 15 year period, while another 50% will cystectomy in an attempt to control their disease. Thus better therapeutic strategies are needed for patients who have failed intravesical therapy. In this article, we report the treatment of a 91-year-old man with NMIBC with high-risk features that had failed multiple intravesical therapies.

Keywords

• Bladder cancer
• Bacillus Calmette–Guérin
• Interleukin 15
• Natural killer
• Non-muscle invasive bladder cancer