Water-electrolyte metabolism disorders in patients with urinary bladder cancer before and after radical surgical treatment

Abstract

We have studied water-electrolyte metabolism indicators and its main hormones-regulators in 32 patients with transitional cell tumour of the urinary bladder of T2a—T2b stages before and after radical cystectomy with ileocystoplasty. The most significant changes in water-electrolyte metabolism indicators have been identified during studies on 24-hour urinary excretion: a significantly large preoperative potassium ion concentration was noted in patients with urinary bladder cancer. Following cystectomy, it decreased to 67%. Postoperative urine osmolarity decreased to 45%, excreting sodium fraction increased to 50% (р < 0,05). Preoperative vasopressin concentration was higher than that in the control group while postoperative one increased to 22%. Following cystectomy, the adrenocorticotrophic hormone level decreased to 29%. Preoperatively, the hydrocortisone level in the basic group was higher than that in the control one. It decreased to 16%, postoperatively. Excretion disorders of osmotic active substances in patients with urinary bladder cancer are due to both reabsorption properties of the intestinal wall and disorders of synthesis and tissue effects of hormones regulating water-electrolyte metabolism.

Keywords

• рак мочевого пузыря
• водно-электролитный обмен
• цистэктомия