On your marks, get SET(D1A): the race to protect stalled replication forks

Abstract

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.

Keywords

• genome stability
• setd1a
• fancd2
• replication stress
• chemoresistance
• chd4