Rational design of aptamer switches with programmable pH response

Ian A. P. Thompson; Liwei Zheng; Michael Eisenstein; H. Tom Soh

doi:10.1038/s41467-020-16808-2

Nature Communications (Jun 2020)

Rational design of aptamer switches with programmable pH response

Ian A. P. Thompson,
Liwei Zheng,
Michael Eisenstein,
H. Tom Soh

Affiliations

Ian A. P. Thompson: Department of Electrical Engineering, Stanford University
Liwei Zheng: Department of Electrical Engineering, Stanford University
Michael Eisenstein: Department of Electrical Engineering, Stanford University
H. Tom Soh: Department of Electrical Engineering, Stanford University

DOI: https://doi.org/10.1038/s41467-020-16808-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 7

Abstract

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Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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