Telomeric RNAs are essential to maintain telomeres

Juan José Montero; Isabel López de Silanes; Osvaldo Graña; Maria A. Blasco

doi:10.1038/ncomms12534

Nature Communications (Aug 2016)

Telomeric RNAs are essential to maintain telomeres

Juan José Montero,
Isabel López de Silanes,
Osvaldo Graña,
Maria A. Blasco

Affiliations

Juan José Montero: Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Isabel López de Silanes: Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
Osvaldo Graña: Bioinformatics Group, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO)
Maria A. Blasco: Telomeres and Telomerase Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)

DOI: https://doi.org/10.1038/ncomms12534
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The telomeric long-non coding RNA, TERRA, has been proposed in the past to modulate different telomeric functions based on in vitrostudies. Here the authors show, using a genetic deletion approach, that TERRA is transcribed from the 20q subtelomere and that it is essential for telomere maintenance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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