FBW7 couples structural integrity with functional output of primary cilia

Eleni Petsouki; Vasileios Gerakopoulos; Nicholas Szeto; Wenhan Chang; Mary Beth Humphrey; Leonidas Tsiokas

doi:10.1038/s42003-021-02504-4

Communications Biology (Sep 2021)

FBW7 couples structural integrity with functional output of primary cilia

Eleni Petsouki,
Vasileios Gerakopoulos,
Nicholas Szeto,
Wenhan Chang,
Mary Beth Humphrey,
Leonidas Tsiokas

Affiliations

Eleni Petsouki: Department of Cell Biology, University of Oklahoma Health Sciences Center
Vasileios Gerakopoulos: Department of Cell Biology, University of Oklahoma Health Sciences Center
Nicholas Szeto: Department of Medicine, Division of Endocrinology and Metabolism, University of California San Francisco
Wenhan Chang: Department of Medicine, Division of Endocrinology and Metabolism, University of California San Francisco
Mary Beth Humphrey: Department of Internal Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center
Leonidas Tsiokas: Department of Cell Biology, University of Oklahoma Health Sciences Center

DOI: https://doi.org/10.1038/s42003-021-02504-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cilia that are necessary for osteoblast differentiation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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