Nature Communications (Feb 2021)
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
- Juliette Coignard,
- Michael Lush,
- Jonathan Beesley,
- Tracy A. O’Mara,
- Joe Dennis,
- Jonathan P. Tyrer,
- Daniel R. Barnes,
- Lesley McGuffog,
- Goska Leslie,
- Manjeet K. Bolla,
- Muriel A. Adank,
- Simona Agata,
- Thomas Ahearn,
- Kristiina Aittomäki,
- Irene L. Andrulis,
- Hoda Anton-Culver,
- Volker Arndt,
- Norbert Arnold,
- Kristan J. Aronson,
- Banu K. Arun,
- Annelie Augustinsson,
- Jacopo Azzollini,
- Daniel Barrowdale,
- Caroline Baynes,
- Heko Becher,
- Marina Bermisheva,
- Leslie Bernstein,
- Katarzyna Białkowska,
- Carl Blomqvist,
- Stig E. Bojesen,
- Bernardo Bonanni,
- Ake Borg,
- Hiltrud Brauch,
- Hermann Brenner,
- Barbara Burwinkel,
- Saundra S. Buys,
- Trinidad Caldés,
- Maria A. Caligo,
- Daniele Campa,
- Brian D. Carter,
- Jose E. Castelao,
- Jenny Chang-Claude,
- Stephen J. Chanock,
- Wendy K. Chung,
- Kathleen B. M. Claes,
- Christine L. Clarke,
- GEMO Study Collaborators,
- EMBRACE Collaborators,
- J. Margriet Collée,
- Don M. Conroy,
- Kamila Czene,
- Mary B. Daly,
- Peter Devilee,
- Orland Diez,
- Yuan Chun Ding,
- Susan M. Domchek,
- Thilo Dörk,
- Isabel dos-Santos-Silva,
- Alison M. Dunning,
- Miriam Dwek,
- Diana M. Eccles,
- A. Heather Eliassen,
- Christoph Engel,
- Mikael Eriksson,
- D. Gareth Evans,
- Peter A. Fasching,
- Henrik Flyger,
- Florentia Fostira,
- Eitan Friedman,
- Lin Fritschi,
- Debra Frost,
- Manuela Gago-Dominguez,
- Susan M. Gapstur,
- Judy Garber,
- Vanesa Garcia-Barberan,
- Montserrat García-Closas,
- José A. García-Sáenz,
- Mia M. Gaudet,
- Simon A. Gayther,
- Andrea Gehrig,
- Vassilios Georgoulias,
- Graham G. Giles,
- Andrew K. Godwin,
- Mark S. Goldberg,
- David E. Goldgar,
- Anna González-Neira,
- Mark H. Greene,
- Pascal Guénel,
- Lothar Haeberle,
- Eric Hahnen,
- Christopher A. Haiman,
- Niclas Håkansson,
- Per Hall,
- Ute Hamann,
- Patricia A. Harrington,
- Steven N. Hart,
- Wei He,
- Frans B. L. Hogervorst,
- Antoinette Hollestelle,
- John L. Hopper,
- Darling J. Horcasitas,
- Peter J. Hulick,
- David J. Hunter,
- Evgeny N. Imyanitov,
- KConFab Investigators,
- HEBON Investigators,
- ABCTB Investigators,
- Agnes Jager,
- Anna Jakubowska,
- Paul A. James,
- Uffe Birk Jensen,
- Esther M. John,
- Michael E. Jones,
- Rudolf Kaaks,
- Pooja Middha Kapoor,
- Beth Y. Karlan,
- Renske Keeman,
- Elza Khusnutdinova,
- Johanna I. Kiiski,
- Yon-Dschun Ko,
- Veli-Matti Kosma,
- Peter Kraft,
- Allison W. Kurian,
- Yael Laitman,
- Diether Lambrechts,
- Loic Le Marchand,
- Jenny Lester,
- Fabienne Lesueur,
- Tricia Lindstrom,
- Adria Lopez-Fernández,
- Jennifer T. Loud,
- Craig Luccarini,
- Arto Mannermaa,
- Siranoush Manoukian,
- Sara Margolin,
- John W. M. Martens,
- Noura Mebirouk,
- Alfons Meindl,
- Austin Miller,
- Roger L. Milne,
- Marco Montagna,
- Katherine L. Nathanson,
- Susan L. Neuhausen,
- Heli Nevanlinna,
- Finn C. Nielsen,
- Katie M. O’Brien,
- Olufunmilayo I. Olopade,
- Janet E. Olson,
- Håkan Olsson,
- Ana Osorio,
- Laura Ottini,
- Tjoung-Won Park-Simon,
- Michael T. Parsons,
- Inge Sokilde Pedersen,
- Beth Peshkin,
- Paolo Peterlongo,
- Julian Peto,
- Paul D. P. Pharoah,
- Kelly-Anne Phillips,
- Eric C. Polley,
- Bruce Poppe,
- Nadege Presneau,
- Miquel Angel Pujana,
- Kevin Punie,
- Paolo Radice,
- Johanna Rantala,
- Muhammad U. Rashid,
- Gad Rennert,
- Hedy S. Rennert,
- Mark Robson,
- Atocha Romero,
- Maria Rossing,
- Emmanouil Saloustros,
- Dale P. Sandler,
- Regina Santella,
- Maren T. Scheuner,
- Marjanka K. Schmidt,
- Gunnar Schmidt,
- Christopher Scott,
- Priyanka Sharma,
- Penny Soucy,
- Melissa C. Southey,
- John J. Spinelli,
- Zoe Steinsnyder,
- Jennifer Stone,
- Dominique Stoppa-Lyonnet,
- Anthony Swerdlow,
- Rulla M. Tamimi,
- William J. Tapper,
- Jack A. Taylor,
- Mary Beth Terry,
- Alex Teulé,
- Darcy L. Thull,
- Marc Tischkowitz,
- Amanda E. Toland,
- Diana Torres,
- Alison H. Trainer,
- Thérèse Truong,
- Nadine Tung,
- Celine M. Vachon,
- Ana Vega,
- Joseph Vijai,
- Qin Wang,
- Barbara Wappenschmidt,
- Clarice R. Weinberg,
- Jeffrey N. Weitzel,
- Camilla Wendt,
- Alicja Wolk,
- Siddhartha Yadav,
- Xiaohong R. Yang,
- Drakoulis Yannoukakos,
- Wei Zheng,
- Argyrios Ziogas,
- Kristin K. Zorn,
- Sue K. Park,
- Mads Thomassen,
- Kenneth Offit,
- Rita K. Schmutzler,
- Fergus J. Couch,
- Jacques Simard,
- Georgia Chenevix-Trench,
- Douglas F. Easton,
- Nadine Andrieu,
- Antonis C. Antoniou
Affiliations
- Juliette Coignard
- Genetic Epidemiology of Cancer team, Inserm, U900
- Michael Lush
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Jonathan Beesley
- Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute
- Tracy A. O’Mara
- Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute
- Joe Dennis
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Jonathan P. Tyrer
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Daniel R. Barnes
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Lesley McGuffog
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Goska Leslie
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Manjeet K. Bolla
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Muriel A. Adank
- Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital
- Simona Agata
- Immunology and Molecular Oncology, Unit Veneto Institute of Oncology IOV – IRCCS
- Thomas Ahearn
- Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- Kristiina Aittomäki
- Department of Clinical Genetics, Helsinki University Hospital University of Helsinki
- Irene L. Andrulis
- Fred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Hoda Anton-Culver
- Department of Epidemiology, Genetic Epidemiology Research Institute University of California Irvine
- Volker Arndt
- Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)
- Norbert Arnold
- Department of Gynaecology and Obstetrics University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel
- Kristan J. Aronson
- Department of Public Health Sciences, and Cancer Research Institute Queen’s University
- Banu K. Arun
- Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center
- Annelie Augustinsson
- Department of Cancer Epidemiology, Clinical Sciences Lund University
- Jacopo Azzollini
- Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
- Daniel Barrowdale
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Caroline Baynes
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Heko Becher
- Institute for Medical Biometrics and Epidemiology University Medical Center Hamburg-Eppendorf
- Marina Bermisheva
- Institute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of Sciences
- Leslie Bernstein
- Department of Population Sciences Beckman Research Institute of City of Hope
- Katarzyna Białkowska
- Department of Genetics and Pathology Pomeranian Medical University Szczecin
- Carl Blomqvist
- Department of Oncology, Helsinki University Hospital University of Helsinki
- Stig E. Bojesen
- Copenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University Hospital
- Bernardo Bonanni
- Division of Cancer Prevention and Genetics IEO, European Institute of Oncology IRCCS
- Ake Borg
- Department of Oncology Lund University and Skåne University Hospital
- Hiltrud Brauch
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)
- Barbara Burwinkel
- Molecular Epidemiology Group, C080 German Cancer Research Center (DKFZ)
- Saundra S. Buys
- Department of Medicine Huntsman Cancer Institute
- Trinidad Caldés
- Molecular Oncology Laboratory CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
- Maria A. Caligo
- SOD Genetica Molecolare University Hospital
- Daniele Campa
- Department of Biology University of Pisa
- Brian D. Carter
- Behavioral and Epidemiology Research Group American Cancer Society Atlanta
- Jose E. Castelao
- Oncology and Genetics Unit Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS
- Jenny Chang-Claude
- Division of Cancer Epidemiology German Cancer Research Center (DKFZ)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- Wendy K. Chung
- Departments of Pediatrics and Medicine, Columbia University
- Kathleen B. M. Claes
- Centre for Medical Genetics Ghent University
- Christine L. Clarke
- Westmead Institute for Medical Research University of Sydney
- GEMO Study Collaborators
- EMBRACE Collaborators
- J. Margriet Collée
- Department of Clinical Genetics Erasmus University Medical Center
- Don M. Conroy
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Kamila Czene
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Mary B. Daly
- Department of Clinical Genetics Fox Chase Cancer Center Philadelphia
- Peter Devilee
- Department of Pathology Leiden University Medical Center
- Orland Diez
- Oncogenetics Group Vall d’Hebron Institute of Oncology (VHIO)
- Yuan Chun Ding
- Department of Population Sciences Beckman Research Institute of City of Hope
- Susan M. Domchek
- Basser Center for BRCA, Abramson Cancer Center University of Pennsylvania
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School
- Isabel dos-Santos-Silva
- Department of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine
- Alison M. Dunning
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Miriam Dwek
- School of Life Sciences University of Westminster
- Diana M. Eccles
- Faculty of Medicine University of Southampton
- A. Heather Eliassen
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- Christoph Engel
- Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig
- Mikael Eriksson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- D. Gareth Evans
- Genomic Medicine, Division of Evolution and Genomic Sciences The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St Mary’s Hospital
- Peter A. Fasching
- David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology University of California at Los Angeles
- Henrik Flyger
- Department of Breast Surgery, Herlev and Gentofte Hospital Copenhagen University Hospital
- Florentia Fostira
- Molecular Diagnostics Laboratory, INRASTES National Centre for Scientific Research íDemokritosí
- Eitan Friedman
- The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center
- Lin Fritschi
- School of Public Health Curtin University
- Debra Frost
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS
- Susan M. Gapstur
- Behavioral and Epidemiology Research Group American Cancer Society Atlanta
- Judy Garber
- Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute
- Vanesa Garcia-Barberan
- Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)
- Montserrat García-Closas
- Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- José A. García-Sáenz
- Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)
- Mia M. Gaudet
- Behavioral and Epidemiology Research Group American Cancer Society Atlanta
- Simon A. Gayther
- Center for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core Cedars-Sinai Medical Center
- Andrea Gehrig
- Department of Human Genetics University Würzburg
- Vassilios Georgoulias
- Department of Medical Oncology University Hospital of Heraklion
- Graham G. Giles
- Cancer Epidemiology Division Cancer Council Victoria
- Andrew K. Godwin
- Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
- Mark S. Goldberg
- Department of Medicine, McGill University
- David E. Goldgar
- Huntsman Cancer Institute and Department of Dermatology, University of Utah School of Medicine
- Anna González-Neira
- Human Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO)
- Mark H. Greene
- Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute
- Pascal Guénel
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP) INSERM, University Paris-Sud, University Paris-Saclay
- Lothar Haeberle
- Department of Gynaecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
- Eric Hahnen
- Center for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of Cologne
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine University of Southern California
- Niclas Håkansson
- Department of Oncology, Södersjukhuset
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Ute Hamann
- Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)
- Patricia A. Harrington
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Steven N. Hart
- Department of Health Sciences Research, Mayo Clinic
- Wei He
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Frans B. L. Hogervorst
- Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital
- Antoinette Hollestelle
- Department of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer Institute
- John L. Hopper
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Darling J. Horcasitas
- New Mexico Oncology Hematology Consultants, University of New Mexico
- Peter J. Hulick
- Center for Medical Genetics NorthShore University HealthSystem
- David J. Hunter
- Department of Epidemiology Harvard TH Chan School of Public Health
- Evgeny N. Imyanitov
- NN Petrov Institute of Oncology
- KConFab Investigators
- HEBON Investigators
- ABCTB Investigators
- Agnes Jager
- Department of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer Institute
- Anna Jakubowska
- Department of Genetics and Pathology Pomeranian Medical University Szczecin
- Paul A. James
- Sir Peter MacCallum Department of Oncology The University of Melbourne
- Uffe Birk Jensen
- Department of Clinical Genetics Aarhus, University Hospital
- Esther M. John
- Department of Medicine, Division of Oncology, Stanford University School of Medicine
- Michael E. Jones
- Department of Epidemiology and Population Health, Stanford University School of Medicine
- Rudolf Kaaks
- Division of Cancer Epidemiology German Cancer Research Center (DKFZ)
- Pooja Middha Kapoor
- Division of Cancer Epidemiology German Cancer Research Center (DKFZ)
- Beth Y. Karlan
- Faculty of Medicine University of Heidelberg
- Renske Keeman
- Womenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center
- Elza Khusnutdinova
- Institute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of Sciences
- Johanna I. Kiiski
- Department of Genetics and Fundamental Medicine Bashkir State Medical University
- Yon-Dschun Ko
- Department of Obstetrics and Gynecology, Helsinki University Hospital University of Helsinki
- Veli-Matti Kosma
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus
- Peter Kraft
- Department of Epidemiology Harvard TH Chan School of Public Health
- Allison W. Kurian
- Department of Medicine, Division of Oncology, Stanford University School of Medicine
- Yael Laitman
- The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center
- Diether Lambrechts
- VIB Center for Cancer Biology
- Loic Le Marchand
- Epidemiology Program University of Hawaii Cancer Center
- Jenny Lester
- Faculty of Medicine University of Heidelberg
- Fabienne Lesueur
- Genetic Epidemiology of Cancer team, Inserm, U900
- Tricia Lindstrom
- Department of Health Sciences Research, Mayo Clinic
- Adria Lopez-Fernández
- High Risk and Cancer Prevention Group Vall d’Hebron Institute of Oncology
- Jennifer T. Loud
- Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute
- Craig Luccarini
- Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge
- Arto Mannermaa
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus
- Siranoush Manoukian
- Unit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
- Sara Margolin
- Department of Oncology, Södersjukhuset
- John W. M. Martens
- Department of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer Institute
- Noura Mebirouk
- Genetic Epidemiology of Cancer team, Inserm, U900
- Alfons Meindl
- Department of Gynecology and Obstetrics University of Munich, Campus Grosshadern
- Austin Miller
- NRG Oncology, Statistics and Data Management Center Roswell Park Cancer Institute
- Roger L. Milne
- Cancer Epidemiology Division Cancer Council Victoria
- Marco Montagna
- Immunology and Molecular Oncology, Unit Veneto Institute of Oncology IOV – IRCCS
- Katherine L. Nathanson
- Basser Center for BRCA, Abramson Cancer Center University of Pennsylvania
- Susan L. Neuhausen
- Department of Population Sciences Beckman Research Institute of City of Hope
- Heli Nevanlinna
- Department of Genetics and Fundamental Medicine Bashkir State Medical University
- Finn C. Nielsen
- Center for Genomic Medicine Rigshospitalet, Copenhagen University Hospital
- Katie M. O’Brien
- Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park
- Olufunmilayo I. Olopade
- Center for Clinical Cancer Genetics The University of Chicago
- Janet E. Olson
- Department of Health Sciences Research, Mayo Clinic
- Håkan Olsson
- Department of Cancer Epidemiology, Clinical Sciences Lund University
- Ana Osorio
- Human Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO)
- Laura Ottini
- Department of Molecular Medicine University La Sapienza
- Tjoung-Won Park-Simon
- Gynaecology Research Unit, Hannover Medical School
- Michael T. Parsons
- Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute
- Inge Sokilde Pedersen
- Molecular Diagnostics Aalborg University Hospital
- Beth Peshkin
- Lombardi Comprehensive Cancer Center, Georgetown University
- Paolo Peterlongo
- Genome Diagnostics Program IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology
- Julian Peto
- Department of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical Medicine
- Paul D. P. Pharoah
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Kelly-Anne Phillips
- Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute
- Eric C. Polley
- Department of Health Sciences Research, Mayo Clinic
- Bruce Poppe
- Centre for Medical Genetics Ghent University
- Nadege Presneau
- School of Life Sciences University of Westminster
- Miquel Angel Pujana
- Translational Research Laboratory IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC
- Kevin Punie
- Leuven Multidisciplinary Breast Center, Department of Oncology Leuven Cancer Institute, University Hospitals Leuven
- Paolo Radice
- Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research Fondazione IRCCS Istituto Nazionale dei Tumori (INT)
- Johanna Rantala
- Clinical Genetics Karolinska Institutet
- Muhammad U. Rashid
- Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)
- Gad Rennert
- Clalit National Cancer Control Center Carmel Medical Center and Technion Faculty of Medicine
- Hedy S. Rennert
- Clalit National Cancer Control Center Carmel Medical Center and Technion Faculty of Medicine
- Mark Robson
- Clinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer Center
- Atocha Romero
- Medical Oncology Department Hospital Universitario Puerta de Hierro
- Maria Rossing
- Center for Genomic Medicine Rigshospitalet, Copenhagen University Hospital
- Emmanouil Saloustros
- Department of Oncology University Hospital of Larissa
- Dale P. Sandler
- Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park
- Regina Santella
- Department of Epidemiology, Mailman School of Public Health Columbia University
- Maren T. Scheuner
- Cancer Genetics and Prevention Program University of California San Francisco
- Marjanka K. Schmidt
- Womenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center
- Gunnar Schmidt
- Institute of Human Genetics Hannover Medical School
- Christopher Scott
- Department of Health Sciences Research, Mayo Clinic
- Priyanka Sharma
- Department of Internal Medicine, Division of Medical Oncology University of Kansas Medical Center
- Penny Soucy
- Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center
- Melissa C. Southey
- Precision Medicine, School of Clinical Sciences at Monash Health Monash University
- John J. Spinelli
- Population Oncology BC Cancer
- Zoe Steinsnyder
- Clinical Genetics Research Lab, Department of Cancer Biology and Genetics Memorial Sloan-Kettering Cancer Center
- Jennifer Stone
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Dominique Stoppa-Lyonnet
- Service de Génétique Institut Curie
- Anthony Swerdlow
- Department of Epidemiology and Population Health, Stanford University School of Medicine
- Rulla M. Tamimi
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
- William J. Tapper
- Faculty of Medicine University of Southampton
- Jack A. Taylor
- Epidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park
- Mary Beth Terry
- Department of Epidemiology, Mailman School of Public Health Columbia University
- Alex Teulé
- Hereditary Cancer Program ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC
- Darcy L. Thull
- Department of Medicine Magee-Womens Hospital, University of Pittsburgh School of Medicine
- Marc Tischkowitz
- Program in Cancer Genetics, Departments of Human Genetics and Oncology McGill University
- Amanda E. Toland
- Department of Cancer Biology and Genetics The Ohio State University
- Diana Torres
- Molecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)
- Alison H. Trainer
- Parkville Familial Cancer Centre Peter MacCallum Cancer Center
- Thérèse Truong
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP) INSERM, University Paris-Sud, University Paris-Saclay
- Nadine Tung
- Department of Medical Oncology Beth Israel Deaconess Medical Center
- Celine M. Vachon
- Department of Health Science Research, Division of Epidemiology Mayo Clinic
- Ana Vega
- Fundación Pública Galega Medicina Xenómica-SERGAS, Instituto de Investigación Sanitaria Santiago de Compostela (IDIS); CIBERER
- Joseph Vijai
- Clinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer Center
- Qin Wang
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Barbara Wappenschmidt
- Center for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of Cologne
- Clarice R. Weinberg
- Biostatistics and Computational Biology Branch National Institute of Environmental Health Sciences, NIH Research Triangle Park
- Jeffrey N. Weitzel
- Clinical Cancer Genomics City of Hope
- Camilla Wendt
- Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet
- Alicja Wolk
- Institute of Environmental Medicine Karolinska Institutet
- Siddhartha Yadav
- Department of Oncology Mayo Clinic
- Xiaohong R. Yang
- Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services
- Drakoulis Yannoukakos
- Molecular Diagnostics Laboratory, INRASTES National Centre for Scientific Research íDemokritosí
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center Vanderbilt University School of Medicine
- Argyrios Ziogas
- Department of Epidemiology, Genetic Epidemiology Research Institute University of California Irvine
- Kristin K. Zorn
- Magee-Womens Hospital, University of Pittsburgh School of Medicine
- Sue K. Park
- Department of Preventive Medicine Seoul National University College of Medicine
- Mads Thomassen
- Department of Clinical Genetics Odense University Hospital
- Kenneth Offit
- Clinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer Center
- Rita K. Schmutzler
- Center for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of Cologne
- Fergus J. Couch
- Department of Laboratory Medicine and Pathology Mayo Clinic
- Jacques Simard
- Department of Epidemiology, Genetic Epidemiology Research Institute University of California Irvine
- Georgia Chenevix-Trench
- Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute
- Douglas F. Easton
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- Nadine Andrieu
- Genetic Epidemiology of Cancer team, Inserm, U900
- Antonis C. Antoniou
- Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-20496-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.
