Multiple Partial Regularized Nonnegative Matrix Factorization for Predicting Ontological Functions of lncRNAs

Abstract

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Long non-coding RNAs (LncRNA) are critical regulators for biological processes, which are highly related to complex diseases. Even though the next generation sequence technology facilitates the discovery of a great number of lncRNAs, the knowledge about the functions of lncRNAs is limited. Thus, it is promising to predict the functions of lncRNAs, which shed light on revealing the mechanisms of complex diseases. The current algorithms predict the functions of lncRNA by using the features of protein-coding genes. Generally speaking, these algorithms fuse heterogeneous genomic data to construct lncRNA-gene associations via a linear combination, which cannot fully characterize the function-lncRNA relations. To overcome this issue, we present an nonnegative matrix factorization algorithm with multiple partial regularization (aka MPrNMF) to predict the functions of lncRNAs without fusing the heterogeneous genomic data. In details, for each type of genomic data, we construct the lncRNA-gene associations, resulting in multiple associations. The proposed method integrates separately them via regularization strategy, rather than fuse them into a single type of associations. The results demonstrate that the proposed algorithm outperforms state-of-the-art methods based network-analysis. The model and algorithm provide an effective way to explore the functions of lncRNAs.

Keywords

• lncRNA
• nonnegative matrix factorization
• gene ontology
• networks
• regularization