Nature Communications (Jul 2020)
B cell zone reticular cell microenvironments shape CXCL13 gradient formation
- Jason Cosgrove,
- Mario Novkovic,
- Stefan Albrecht,
- Natalia B. Pikor,
- Zhaoukun Zhou,
- Lucas Onder,
- Urs Mörbe,
- Jovana Cupovic,
- Helen Miller,
- Kieran Alden,
- Anne Thuery,
- Peter O’Toole,
- Rita Pinter,
- Simon Jarrett,
- Emily Taylor,
- Daniel Venetz,
- Manfred Heller,
- Mariagrazia Uguccioni,
- Daniel F. Legler,
- Charles J. Lacey,
- Andrew Coatesworth,
- Wojciech G. Polak,
- Tom Cupedo,
- Bénedicte Manoury,
- Marcus Thelen,
- Jens V. Stein,
- Marlene Wolf,
- Mark C. Leake,
- Jon Timmis,
- Burkhard Ludewig,
- Mark C. Coles
Affiliations
- Jason Cosgrove
- York Computational Immunology Lab, University of York
- Mario Novkovic
- Institute of Immunobiology, Kantonsspital St. Gallen
- Stefan Albrecht
- Theodor Kocher Institute, University of Bern
- Natalia B. Pikor
- Institute of Immunobiology, Kantonsspital St. Gallen
- Zhaoukun Zhou
- Department of Biology, University of York
- Lucas Onder
- Institute of Immunobiology, Kantonsspital St. Gallen
- Urs Mörbe
- Institute of Immunobiology, Kantonsspital St. Gallen
- Jovana Cupovic
- Institute of Immunobiology, Kantonsspital St. Gallen
- Helen Miller
- Department of Biology, University of York
- Kieran Alden
- York Computational Immunology Lab, University of York
- Anne Thuery
- Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
- Peter O’Toole
- Department of Biology, University of York
- Rita Pinter
- Kennedy Institute of Rheumatology at the University of Oxford
- Simon Jarrett
- Kennedy Institute of Rheumatology at the University of Oxford
- Emily Taylor
- Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York
- Daniel Venetz
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Manfred Heller
- Department of Clinical Research, University of Bern
- Mariagrazia Uguccioni
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Daniel F. Legler
- Biotechnology Institute Thurgau (BITg) at the University of Konstanz
- Charles J. Lacey
- York Computational Immunology Lab, University of York
- Andrew Coatesworth
- York Teaching Hospital NHS Foundation Trust
- Wojciech G. Polak
- Department of Surgery, Erasmus University Medical Centre
- Tom Cupedo
- Department of Hematology, Erasmus University Medical Centre
- Bénedicte Manoury
- Institut Necker Enfants Malades, INSERM U1151- CNRS UMR 8253, 149 rue de Sèvres 75015 Paris, France Université René Descartes
- Marcus Thelen
- Institute for Research in Biomedicine, Università della Svizzera italiana
- Jens V. Stein
- Department of Oncology, Microbiology and Immunology, University of Fribourg
- Marlene Wolf
- Theodor Kocher Institute, University of Bern
- Mark C. Leake
- Department of Biology, University of York
- Jon Timmis
- York Computational Immunology Lab, University of York
- Burkhard Ludewig
- Institute of Immunobiology, Kantonsspital St. Gallen
- Mark C. Coles
- York Computational Immunology Lab, University of York
- DOI
- https://doi.org/10.1038/s41467-020-17135-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.
