Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

Cheng Sun; Peixiang Lan; Qiuju Han; Mei Huang; Zhihong Zhang; Geliang Xu; Jiaxi Song; Jinyu Wang; Haiming Wei; Jian Zhang; Rui Sun; Cai Zhang; Zhigang Tian

doi:10.1038/s41467-018-03584-3

Nature Communications (Mar 2018)

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

Cheng Sun,
Peixiang Lan,
Qiuju Han,
Mei Huang,
Zhihong Zhang,
Geliang Xu,
Jiaxi Song,
Jinyu Wang,
Haiming Wei,
Jian Zhang,
Rui Sun,
Cai Zhang,
Zhigang Tian

Affiliations

Cheng Sun: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China
Peixiang Lan: Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University
Qiuju Han: Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University
Mei Huang: Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University
Zhihong Zhang: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology
Geliang Xu: Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University
Jiaxi Song: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China
Jinyu Wang: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China
Haiming Wei: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China
Jian Zhang: Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University
Rui Sun: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China
Cai Zhang: Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University
Zhigang Tian: The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-03584-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Blocking PD-1 function on T cells is thought to be a viable strategy to prevent virus-induced or tumor-induced T cell exhaustion. Here the authors link the zinc-finger transcription factor SALL4 with miR-200c inhibition of PD-L1 expression by hepatocytes in patients with HBV-induced hepatocellular carcinoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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