New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

Prodip K. Roy; Runa Ashimine; Haruna Miyazato; Junsei Taira; Katsuhiro Ueda

doi:10.3390/molecules21050679

Molecules (May 2016)

New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

Prodip K. Roy,
Runa Ashimine,
Haruna Miyazato,
Junsei Taira,
Katsuhiro Ueda

Affiliations

Prodip K. Roy: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan
Runa Ashimine: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan
Haruna Miyazato: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-shi, Okinawa 905-2192, Japan
Junsei Taira: Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-shi, Okinawa 905-2192, Japan
Katsuhiro Ueda: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan

DOI: https://doi.org/10.3390/molecules21050679
Journal volume & issue: Vol. 21, no. 5
p. 679

Abstract

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A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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