Zbornik Matice Srpske za Prirodne Nauke (Jan 2021)

Determination of tropane alkaloids in corn puffs by the LC-MS/MS

  • Stojanović Tijana N.,
  • Vuković Gorica Lj.,
  • Petrović Aleksandra P.,
  • Konstantinović Bojan B.,
  • Puvača Nikola M.,
  • Marinković Dušan S.,
  • Gvozdenac Sonja M.,
  • Bursić Vojislava P.

DOI
https://doi.org/10.2298/ZMSPN2141069S
Journal volume & issue
Vol. 2021, no. 141
pp. 69 – 80

Abstract

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The interest in tropane alkaloids (TA) as food contaminants is increasing. A sensitive and selective LC-MS/MS method was applied for the analysis of corn puff samples from the Serbian market. Only atropine was quantified in 22% of the samples. In case of scopolamine, although not quantified, it was detected in 22% of the samples. Whether the acute reference dose (ARfD) could be exceeded was checked on a case-by-case basis for the individual products under assessment. Due to their low body weight and relatively high snack consumption, preschool children were at the highest risk of TA exposure. Assuming that the average consumption is 50 g of corn puffs per day, the sample with the highest concentration of TAs (2.05 μg/kg, 1.58 μg/kg of atropine) could contribute with 32.0% to the ARfD, of which 24.7% owing to atropine. If the same amount of corn puffs is consumed by older age classes, corresponding exposure contributions to the ARfD would progressively decline, down to 8.4% for adult population. The study revealed no health risk from TAs exposure through the consumption of the corn puffs in Serbian population.

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