Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes

Sofie De Moudt; Jhana O. Hendrickx; Cédric Neutel; Dorien De Munck; Arthur Leloup; Guido R. Y. De Meyer; Wim Martinet; Paul Fransen

doi:10.1038/s42003-022-03563-x

Communications Biology (Jun 2022)

Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes

Sofie De Moudt,
Jhana O. Hendrickx,
Cédric Neutel,
Dorien De Munck,
Arthur Leloup,
Guido R. Y. De Meyer,
Wim Martinet,
Paul Fransen

Affiliations

Sofie De Moudt: Laboratory of Physiopharmacology, University of Antwerp
Jhana O. Hendrickx: Laboratory of Physiopharmacology, University of Antwerp
Cédric Neutel: Laboratory of Physiopharmacology, University of Antwerp
Dorien De Munck: Laboratory of Physiopharmacology, University of Antwerp
Arthur Leloup: Laboratory of Physiopharmacology, University of Antwerp
Guido R. Y. De Meyer: Laboratory of Physiopharmacology, University of Antwerp
Wim Martinet: Laboratory of Physiopharmacology, University of Antwerp
Paul Fransen: Laboratory of Physiopharmacology, University of Antwerp

DOI: https://doi.org/10.1038/s42003-022-03563-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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A 24-month aging study in male C57Bl/6 mice reveals that aortic aging precedes cardiovascular disease and is due to changes in the extracellular matrix and vascular smooth muscle cell signaling.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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