Catalyst-free synthesis of tetrahydrodipyrazolopyridines via an one-pot tandem and green pseudo-six-component reaction in water

Abstract

Abstract Background A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, FTIR, NMR and Mass spectroscopy. Results The tetrahydrodipyrazolopyridine derivatives were synthesized in water through a catalyst-free pseudo-six-component reaction of hydrazine hydrate, ethyl acetoacetate, ammonium acetate and aldehyde at room temperature. Conclusions This novel procedure has some advantages such as aqueous media, high yield and simple work-up. Graphical Abstract

Keywords

• Tetrahydrodipyrazolopyridines (THDPP’s)
• Multicomponent reaction
• Environmentally friendly protocol
• Catalyst-free reaction