Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Stefania Arasi; Ulugbek Nurmatov; Paul J. Turner; Ignacio J. Ansotegui; Shahd Daher; Audrey Dunn-Galvin; Motohiro Ebisawa; Philippe Eigenmann; Montserrat Fernandez-Rivas; Ruchi Gupta; Anna Nowak-Wegrzyn; Stavros Petrou; Graham Roberts; Mario A. Sánchez Borges; Sayantani B. Sindher; Luciana Kase Tanno; Marta Vazquez-Ortiz; Brian P. Vickery; Gary Wing-Kin Wong; Alessandro Fiocchi

World Allergy Organization Journal (Dec 2020)

Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Stefania Arasi,
Ulugbek Nurmatov,
Paul J. Turner,
Ignacio J. Ansotegui,
Shahd Daher,
Audrey Dunn-Galvin,
Motohiro Ebisawa,
Philippe Eigenmann,
Montserrat Fernandez-Rivas,
Ruchi Gupta,
Anna Nowak-Wegrzyn,
Stavros Petrou,
Graham Roberts,
Mario A. Sánchez Borges,
Sayantani B. Sindher,
Luciana Kase Tanno,
Marta Vazquez-Ortiz,
Brian P. Vickery,
Gary Wing-Kin Wong,
Alessandro Fiocchi

Affiliations

Stefania Arasi: Predictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy; Corresponding author. Pediatric Allergology Unit, Bambino Gesù Hospital (IRCCS), Piazza S. Onofrio, 00161, Rome, Italy
Ulugbek Nurmatov: Division of Population Medicine, School of Medicine, Cardiff University, Wales, UK
Paul J. Turner: National Heart & Lung Institute, Imperial College London, London, UK; Discipline of Paediatrics and Child Health, School of Medicine, University of Sydney, Sydney, Australia
Ignacio J. Ansotegui: Dept. Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
Shahd Daher: Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UK
Audrey Dunn-Galvin: Applied Psychology and Paediatrics and Child Health, University College Cork, Cork, Ireland
Motohiro Ebisawa: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan
Philippe Eigenmann: Pediatric Allergy Unit, Department of Women-Children-Teenagers Pediatrics, University Hospitals of Geneva, Geneva, Switzerland
Montserrat Fernandez-Rivas: Servicio de Alergia, Hospital Clınico San Carlos, UCM, IdISSC, ARADyAL, Madrid, Spain
Ruchi Gupta: Center for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine; Department of Pediatrics & Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, USA
Anna Nowak-Wegrzyn: Allergy and Immunology, Department of Pediatrics, New York University School of Medicine, Langone Health, New York, NY, USA; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
Stavros Petrou: Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UK
Graham Roberts: NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Clinical and Experimental Sciences and Human Development in Health, Faculty of Medicine, University of Southampton, Southampton, UK; The David Hide Asthma and Allergy Research Centre, St Mary’s Hospital, Isle of Wight, UK
Mario A. Sánchez Borges: Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela
Sayantani B. Sindher: Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA
Luciana Kase Tanno: Hospital Sírio Libanês, São Paulo, Brazil; University Hospital of Montpellier; Sorbonne Universités, Paris, Montpellier, France
Marta Vazquez-Ortiz: Department of Paediatrics, Imperial College, London, United Kingdom
Brian P. Vickery: Department of Pediatrics, Emory University, Atlanta, GA, USA
Gary Wing-Kin Wong: Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
Alessandro Fiocchi: Predictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy

Journal volume & issue: Vol. 13, no. 12
p. 100493

Abstract

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Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised. Ethics and dissemination: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated. PROSPERO registration number: CRD42020183103.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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