Azo group-enabled metal- and oxidant-free alkenyl C–H thiolation: Access to stereodefined tetrasubstituted acyclic olefins

Abstract

Metal- and oxidant-free alkenyl C–H thiolation enabled by the azo group had been established for the modular synthesis of tetrasubstituted acyclic olefins. The reaction was performed under mild reaction conditions with a broad substrate scope. The intramolecular 6-membered hydrogen-bonding network accounts for the observed excellent stereo-control.

Keywords

• Tetrasubstituted acyclic olefins
• Azo group
• C–H thiolation
• Metal-free