Nature Communications (Apr 2020)

Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion

  • Julia A. Horstmann,
  • Michele Lunelli,
  • Hélène Cazzola,
  • Johannes Heidemann,
  • Caroline Kühne,
  • Pascal Steffen,
  • Sandra Szefs,
  • Claire Rossi,
  • Ravi K. Lokareddy,
  • Chu Wang,
  • Laurine Lemaire,
  • Kelly T. Hughes,
  • Charlotte Uetrecht,
  • Hartmut Schlüter,
  • Guntram A. Grassl,
  • Theresia E. B. Stradal,
  • Yannick Rossez,
  • Michael Kolbe,
  • Marc Erhardt

DOI
https://doi.org/10.1038/s41467-020-15738-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

Flagellin proteins of Salmonella flagella are methylated. Here, the authors show that flagellin methylation facilitates adhesion of Salmonella to hydrophobic host-cell surfaces, and contributes to efficient gut colonization and host infection.