Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

Abstract

The molecular mechanisms regulating skin dermal changes are unclear. Here, the authors show that deletion of Hedgehog (Hh) in the upper dermis alters the response to epidermal Wnt signalling, which, together with changes in extracellular matrix production, influences distinct fibroblast lineages differently.