Nature Communications (Jan 2021)
Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer
- Gillian Vandekerkhove,
- Jean-Michel Lavoie,
- Matti Annala,
- Andrew J. Murtha,
- Nora Sundahl,
- Simon Walz,
- Takeshi Sano,
- Sinja Taavitsainen,
- Elie Ritch,
- Ladan Fazli,
- Antonio Hurtado-Coll,
- Gang Wang,
- Matti Nykter,
- Peter C. Black,
- Tilman Todenhöfer,
- Piet Ost,
- Ewan A. Gibb,
- Kim N. Chi,
- Bernhard J. Eigl,
- Alexander W. Wyatt
Affiliations
- Gillian Vandekerkhove
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Jean-Michel Lavoie
- Department of Medical Oncology, BC Cancer
- Matti Annala
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Andrew J. Murtha
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Nora Sundahl
- Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital
- Simon Walz
- Department of Urology, University Hospital Tübingen
- Takeshi Sano
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Sinja Taavitsainen
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre
- Elie Ritch
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Ladan Fazli
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Antonio Hurtado-Coll
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Gang Wang
- Department of Pathology and Laboratory Medicine, BC Cancer
- Matti Nykter
- Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre
- Peter C. Black
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Tilman Todenhöfer
- Studienpraxis Urologie
- Piet Ost
- Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital
- Ewan A. Gibb
- Decipher Biosciences, Inc.
- Kim N. Chi
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- Bernhard J. Eigl
- Department of Medical Oncology, BC Cancer
- Alexander W. Wyatt
- Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia
- DOI
- https://doi.org/10.1038/s41467-020-20493-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
In metastatic urothelial carcinoma, it has not been established whether circulating tumor DNA (ctDNA) can replace archival primary tissue to assess mutations and biomarkers. Here, the authors show high mutation concordance between ctDNA and tumour tissue, with high consistency in serial samples.
