Gata6+ resident peritoneal macrophages promote the growth of liver metastasis

Mokarram Hossain; Raymond Shim; Woo-Yong Lee; Arlene H. Sharpe; Paul Kubes

doi:10.1038/s41467-022-32080-y

Nature Communications (Jul 2022)

Gata6+ resident peritoneal macrophages promote the growth of liver metastasis

Mokarram Hossain,
Raymond Shim,
Woo-Yong Lee,
Arlene H. Sharpe,
Paul Kubes

Affiliations

Mokarram Hossain: Department of Physiology and Pharmacology, University of Calgary
Raymond Shim: Department of Physiology and Pharmacology, University of Calgary
Woo-Yong Lee: Snyder Institute for Chronic Diseases, University of Calgary
Arlene H. Sharpe: Department of Immunology, Blavatnik Institute, Harvard Medical School, and Evergrande Centre for Immunological Diseases, Harvard Medical School and Brigham and Women’s Hospital
Paul Kubes: Department of Physiology and Pharmacology, University of Calgary

DOI: https://doi.org/10.1038/s41467-022-32080-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

Read online

GLPMs represent a population of fetal liver derived large peritoneal cavity Gata6+ macrophages, with the capacity to invade the tissues they surround. Here, in experimental colon cancer liver metastasis models, the authors show that GLPMs invade liver metastasis directly from the peritoneum, promoting liver metastases growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal