Oculogyric crisis symptoms related to risperidone treatment: a case report

Abstract

Abstract Background Oculogyric crisis (OGC) is a rare focal dystonia of the ocular muscles that not only interferes with patients’ medication adherence but also negatively affects the course and prognosis of the primary disease. Early detection and treatment of OGC can improve patients’ medication adherence and quality of life. Case presentation This paper reports a case of a 19-year-old Asian female with a diagnosis of schizophrenia who was treated intermittently with atypical antipsychotics aripiprazole or risperidone for 2 years, with improvement of psychotic symptoms during the course of medication, and then developed double eye rolling and staring with irritability when treated with risperidone 4 mg/d or 6 mg/d. Then, we changed the medication to clozapine, and the patient’s psychotic symptoms were controlled and stable. The symptoms of double eye rolling and gaze disappeared. Conclusion Oculogyric crisis (OGC) is a rare focal dystonia of the oculogyric muscle. This case provides clinicians with a basis for the early recognition and management of oculogyric crisis during the use of atypical antipsychotics (risperidone).

Keywords

• Risperidone
• Clozapine
• Oculogyric crisis
• Therapeutic drug monitoring