BIOFILM FORMATION OF STAPHYLOCOCCUS AUREUS, SALMONELLA ENTERITIDIS AND PSEUDOMONAS AERUGINOSA IN PRESENCE OF N-BENZOTIAZOL-2-YL-BENZENSULFONAMIDE DERIVATIVES

Abstract

It was shown that the growth and biofilm formation of Staphylococcus aureus, Salmonella enteritidis and Pseudomonas aeruginosa decreased in the presence of N-benzotiazol-2-yl-benzensulfonamide (compound I) and its derivatives with nucleophylic radicals (compounds II, III and IV) in depending on a dose manner. The inhibitory effect of these compounds on S. aureus did not depend on their structures. At the same time, the derivatives with nucleophylic radicals were more effective against gram-negative bacteria then compound I. Biofilm formation by S. aureus was inhibited by all the compounds and was not dependent on their structure. In the same time analogs with nucleophylic derivatives showed higher activity on gram-negetive bacteria biofilm instead compound I. The highest activity for compounds III and IV were detected in concentration of 80 mkM. In this case S. aureus biofilm was inhibited by the 5.4 times, P. aeruginosa – by 8.4 times, S. еnteritidis – by 4.9 times.

Keywords

• біоплівка
• біомаса планктонної культури
• n-бензотіазол-2-іл-бензенсульфонамід
• похідні з нуклеофільними замісниками